Original paper
Non-active site mutants of HIV-1 protease influence resistance and sensitisation towards protease inhibitors
Abstract
Background HIV-1 can develop resistance to antiretroviral drugs, mainly through mutations within the target regions of the drugs. In HIV-1 protease, a majority of resistance-associated mutations that develop in response to therapy with protease inhibitors are found in the protease’s active site that serves also as a binding pocket for the protease inhibitors, thus directly impacting the protease-inhibitor interactions. Some resistance-associated...
Paper Details
Title
Non-active site mutants of HIV-1 protease influence resistance and sensitisation towards protease inhibitors
Published Date
May 19, 2020
Journal
Volume
17
Issue
1
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Notes
History