Molecular state evaluation of active pharmaceutical ingredients in adhesive patches for transdermal drug delivery

In this study, we prepared mock patches consisting of model drug (felbinac) and three types of acrylic polymers with different functional substituent and/or physical properties, and evaluated the correlation of pharmaceutical properties and molecular state of felbinac in these patches. Polarizing microscopic observation, powder X-ray diffraction and Raman spectroscopy were employed and then different propensity was observed in the...