Original paper
CD24 blunts the sensitivity of retinoblastoma to vincristine by modulating autophagy
Abstract
Retinoblastoma (RB) is the most common childhood malignant intraocular tumor. The clinical efficacy of vincristine (VCR) in the treatment of RB is severely limited by drug resistance. Here, we found that CD24, a GPI‐anchored protein, was overexpressed in human RB tissues and RB cell lines, and was associated with the sensitivity of RB cells in response to VCR therapy. We demonstrated that CD24 plays a critical role in impairing RB sensitivity to...
Paper Details
Title
CD24 blunts the sensitivity of retinoblastoma to vincristine by modulating autophagy
Published Date
Jun 13, 2020
Journal
Volume
14
Issue
8
Pages
1740 - 1759
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Notes
History