Match!

Antioxidant modulation of sirtuin 3 during acute inflammatory pain: The ROS control.

Published on May 11, 2020in Pharmacological Research5.574
· DOI :10.1016/J.PHRS.2020.104851
Sara Ilari6
Estimated H-index: 6
,
Luigino Antonio Giancotti2
Estimated H-index: 2
(SLU: Saint Louis University)
+ 12 AuthorsMatteo A. Russo34
Estimated H-index: 34
(OU: Open University)
Abstract
Abstract Oxidative stress induced post-translational protein modifications are associated with the development of inflammatory hypersensitivities. At least 90% of cellular reactive oxygen species (ROS) are produced in the mitochondria, where the mitochondrial antioxidant, manganese superoxide dismutase (MnSOD), is located. MnSOD’s ability to reduce ROS is enhanced by the mitochondrial NAD+-dependent deacetylase sirtuin (SIRT3). SIRT3 can reduce ROS levels by deacetylating MnSOD and enhancing its ability to neutralize ROS or by enhancing the transcription of MnSOD and other oxidative stress-responsive genes. SIRT3 can be post-translationally modified through carbonylation which results in loss of activity. The contribution of post-translational SIRT3 modifications in central sensitization is largely unexplored. Our results reveal that SIRT3 carbonylation contributes to spinal MnSOD inactivation during carrageenan-induced thermal hyperalgesia in rats. Moreover, inhibiting ROS with natural and synthetic antioxidants, prevented SIRT3 carbonylation, restored the enzymatic activity of MnSOD, and blocked the development of thermal hyperalgesia. These results suggest that therapeutic strategies aimed at inhibiting post-translational modifications of SIRT3 may provide beneficial outcomes in pain states where ROS have been documented to play an important role in the development of central sensitization.
  • References (78)
  • Citations (0)
📖 Papers frequently viewed together
19 Citations
7 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
References78
Newest
#1Zhao Yan (Fourth Military Medical University)H-Index: 2
#2Shu Zhu (Fourth Military Medical University)H-Index: 1
Last. Xiaorui Cao (Fourth Military Medical University)H-Index: 6
view all 11 authors...
Abstract The Mitochondrial-derived peptide MOTS-c has recently been reported as a 16-amino acid peptide regulating metabolism and homeostasis in different cells. However, its effects on immune cells and bone metabolism are rarely reported. Here we demonstrate that MOTS-c treatment in ultra-high molecular weight polyethylene (UHMWPE) particle-induced osteolysis mouse model alleviated bone erosion and inflammation. MOTS-c increased osteoprotegerin (OPG)/ receptor activator of nuclear factor kappa-...
1 CitationsSource
#1Oh Yoen Kim (Dong-a University)H-Index: 29
#2Ji Yeon Chung (Chosun University)
Last. Juhyun Song (Chonnam National University)H-Index: 2
view all 3 authors...
Abstract Obesity is a globally widespread metabolic disorder, characterized by immoderate fat accumulation in the body. There are different types of body fats such as white adipose tissue (WAT), which stores surplus energy in the body, and brown adipose tissue (BAT) which utilize energy to produce heat during metabolism. BAT acts many beneficial functions in metabolic disorders including type 2 diabetes and obesity. Recent studies have investigated methods for promoting the fat browning process ...
Source
#1Cinthya Echem (USP: University of São Paulo)H-Index: 3
#2Tiago J. Costa (USP: University of São Paulo)H-Index: 4
Last. Maria Helena Catelli de Carvalho (USP: University of São Paulo)H-Index: 32
view all 12 authors...
Abstract The prevalence of arterial hypertension (AH) is higher in men than in premenopausal women of the same age. AH has been characterized as a chronic inflammatory disease and activation of Toll-like receptors (TLR) by damage-associated molecular patterns (DAMPs) is involved. Mitochondrial DNA (mtDNA) may be released by end-organ damage, which is recognized and activates TLR9. The serum level of mtDNA is increased in AH. The aim of this study was to compare the serum mtDNA levels between mal...
1 CitationsSource
#1Wai San Cheang (UM: University of Macau)H-Index: 15
#2Wing-Tak Wong (CUHK: The Chinese University of Hong Kong)H-Index: 53
Last. Xiao Yu Tian (CUHK: The Chinese University of Hong Kong)H-Index: 30
view all 10 authors...
Abstract Sirtuin 1 (SIRT1) activation reduces oxidative stress, inhibits inflammatory responses, and retards cellular senescence in endothelial cells in mouse models of diabetes. However, whether SIRT1 also plays a protective role in vascular dysfunction of diabetic and obese mice is not fully characterized. Previous work showed that peroxisome proliferator-activated receptor δ (PPARδ) is beneficial in diabetic vascular dysfunction. Whether PPARδ is involved in the beneficial effect of SIRT1 on ...
1 CitationsSource
#1Jan Skoda (Masaryk University)H-Index: 6
#2Karolina Borankova (Masaryk University)H-Index: 1
Last. Des R. Richardson (Masaryk University)H-Index: 71
view all 6 authors...
Abstract Mitochondria play vital roles in various cellular processes, ranging from cellular metabolism to signal transduction and cell death regulation. As these properties are critical for cancer growth, the mitochondrion has recently become an attractive target for anti-cancer therapies. In addition, it has come to light that mitochondria are crucially involved in the regulation of stem cell identity, differentiation and fate. A similar role for mitochondria has been also demonstrated in malig...
10 CitationsSource
#1Erin M. Rock (U of G: University of Guelph)H-Index: 15
#2Cheryl L. Limebeer (U of G: University of Guelph)H-Index: 23
Last. Linda A. Parker (U of G: University of Guelph)H-Index: 47
view all 3 authors...
5 CitationsSource
#1Tufan Mert (Kahramanmaraş Sütçü İmam University)H-Index: 14
#2Emel Sahin (Kahramanmaraş Sütçü İmam University)H-Index: 1
Last. Mehmet Sahin (Kahramanmaraş Sütçü İmam University)H-Index: 1
view all 4 authors...
In this study, we tested our working hypothesis that inhibiting the activation of microglia by systemic minocycline treatments can decrease the dosage of local tramadol injection in inflammatory pain. This study was therefore aimed to evaluate the actions of intraplantarly injected tramadol, intraperitoneally injected minocycline, or their combined treatments on the inflammation-induced hypernociception (thermal hyperalgesia, mechanical allodynia), edema, and pro- and anti-inflammatory cytokine ...
2 CitationsSource
#1Adi Y. Berman (Yeshiva University)H-Index: 3
#2Rachel A. Motechin (Yeshiva University)H-Index: 1
Last. Marina K. Holz (Yeshiva University)H-Index: 16
view all 4 authors...
Resveratrol is a nutraceutical with several therapeutic effects. It has been shown to mimic effects of caloric restriction, exert anti-inflammatory and anti-oxidative effects, and affect the initiation and progression of many diseases through several mechanisms. While there is a wealth of in vitro and in vivo evidence that resveratrol could be a promising therapeutic agent, clinical trials must confirm its potential. In this work, we reviewed the current clinical data available regarding the pha...
107 CitationsSource
#1Tingting Ren (Fourth Military Medical University)H-Index: 7
#2Haifeng Zhang (Fourth Military Medical University)H-Index: 33
Last. Jun-Ling Xing (Fourth Military Medical University)H-Index: 14
view all 11 authors...
MCU-dependent mitochondrial Ca 2+ inhibits NAD + /SIRT3/SOD2 pathway to promote ROS production and metastasis of HCC cells
27 CitationsSource
#1Ajeet Singh (BHU: Banaras Hindu University)H-Index: 5
#2Manjula Vinayak (BHU: Banaras Hindu University)H-Index: 17
Objectives Impact of ROS in development of hyperalgesia has recently motivated scientists to focus on ROS as novel target of anti-hyperalgesic interventions. However, role of ROS in molecular signaling of hyperalgesia is still poorly understood. The present study is aimed to analyze the effect of dietary antioxidant resveratrol on antioxidant defense system, ROS level and TNFR1–ERK signaling pathway during early and late phase of inflammatory hyperalgesia.
4 CitationsSource
Cited By0
Newest