Original paper
MCH Neurons Regulate Permeability of the Median Eminence Barrier
Abstract
Melanin-concentrating hormone (MCH)-expressing neurons are key regulators of energy and glucose homeostasis. Here, we demonstrate that they provide dense projections to the median eminence (ME) in close proximity to tanycytes and fenestrated vessels. Chemogenetic activation of MCH neurons as well as optogenetic stimulation of their projections in the ME enhance permeability of the ME by increasing fenestrated vascular loops and enhance leptin...
Paper Details
Title
MCH Neurons Regulate Permeability of the Median Eminence Barrier
Published Date
Jul 1, 2020
Journal
Volume
107
Issue
2
Pages
306 - 319.e9
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Notes
History