Original paper
Genotoxic stress triggers the activation of IRE1α-dependent RNA decay to modulate the DNA damage response
Abstract
The molecular connections between homeostatic systems that maintain both genome integrity and proteostasis are poorly understood. Here we identify the selective activation of the unfolded protein response transducer IRE1α under genotoxic stress to modulate repair programs and sustain cell survival. DNA damage engages IRE1α signaling in the absence of an endoplasmic reticulum (ER) stress signature, leading to the exclusive activation of regulated...
Paper Details
Title
Genotoxic stress triggers the activation of IRE1α-dependent RNA decay to modulate the DNA damage response
Published Date
May 14, 2020
Journal
Volume
11
Issue
1
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Notes
History