A unifying model of glucotoxicity in human renal proximal tubular epithelial cells and the effect of the SGLT2 inhibitor dapagliflozin
Volume: 52, Issue: 6, Pages: 1179 - 1189
Published: May 2, 2020
Abstract
Glucotoxicity in renal tubular epithelial cells (RPTECs) contributes to the pathogenesis of diabetic nephropathy. Sodium-glucose cotransporter 2 (SGLT2) inhibitors may exert their renoprotective effect by preventing glucotoxicity. We tested whether the confirmed in capillary endothelial cells unifying model of glucotoxicity can be applied in RPTECs and the impact of dapagliflozin. In primary human RPTECs cultured in normal or high glucose medium...
Paper Details
Title
A unifying model of glucotoxicity in human renal proximal tubular epithelial cells and the effect of the SGLT2 inhibitor dapagliflozin
Published Date
May 2, 2020
Volume
52
Issue
6
Pages
1179 - 1189
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