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International Urology and Nephrology
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Papers 6466
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BACKGROUND: Uremic pruritus (UP) is a highly prevalent and disturbing problem in patients with advanced chronic kidney disease (CKD); however, treatment of UP is largely unsatisfactory. The present study was designed to investigate the effectiveness of mirtazapine, an atypical antidepressant agent with potent antagonistic activity against serotonin (5HT2, 5HT3) and histamine (H1) receptors, in the treatment of pruritus in hemodialysis (HD) patients. METHODS: An 8-week long, prospective, open-lab...
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#1Jie Weng (WMU: Wenzhou Medical College)H-Index: 2
#2Jingwen Yang (WMU: Wenzhou Medical College)
Last. Zhiyi Wang (WMU: Wenzhou Medical College)H-Index: 2
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#1Xuejiao Wei (JLU: Jilin University)
#2Xiao-Yu Zhu (JLU: Jilin University)H-Index: 1
Last. Yujun Du (JLU: Jilin University)H-Index: 5
view all 7 authors...
Renal fibrosis is the most common pathological manifestation of chronic kidney disease (CKD), and with numerous influencing factors, its pathogenesis is complex. Epithelial-mesenchymal transition (EMT) is known to promote the progression of renal fibrosis via alterations in the secreted proteome. Moreover, blocking or even reversing EMT can effectively reduce the degree of fibrosis. As such, targeting the key molecules responsible for promoting EMT may be an effective strategy for inhibiting ren...
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#1Zaizhu Zhang (Peking Union Medical College Hospital)
#2Wei Yu (Peking Union Medical College Hospital)H-Index: 11
Last. Qiang Lin (Peking Union Medical College Hospital)H-Index: 2
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#1M Francesca Monn (EVMS: Eastern Virginia Medical School)
Last. Ramon Virasoro (EVMS: Eastern Virginia Medical School)H-Index: 9
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PURPOSE: Adult acquired buried penis (AABP) can present with concomitant Lichen Sclerosus (LS), a chronic dermatosis that may affect surgical outcomes. Our aim was to evaluate outcomes of patients undergoing AABP repair with and without LS. METHODS: A retrospective cohort study was performed for AABP repair patients at a single institution from 1/1991 to 12/2017. Patient characteristics and surgical and peri-operative outcomes, including success, erectile function, and complications, were collec...
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OBJECTIVE: To determine risk factors for in-hospital mortality in elderly patients with acute kidney injury (AKI) requiring dialysis. INTRODUCTION: AKI requiring dialysis is frequent in elderly and is associated with an increased intra-hospital mortality. With the growing number of older individuals among hospitalized patients with AKI demands a thorough investigation of the factors that contribute to their mortality to improve outcomes. METHODS: We performed a retrospective analysis of patients...
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#1Qian Zhang (Fudan University)H-Index: 5
#2Jia-ying Zhang (Fudan University)H-Index: 1
Last. Jing Chen (Fudan University)H-Index: 16
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PURPOSE: Protein-energy wasting, characterized by decreased muscle mass, is one of the strongest predictors of mortality in patients on maintenance hemodialysis (MHD). As people get older, their muscle strength usually declines faster than muscle mass. However, the association between lower-limb muscle strength and all-cause mortality remains unclear. We aimed to evaluate risk factors for decreased upper-limb muscle strength in MHD patients and its impact on patient survival. METHODS: The cross-...
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#1Theodoros Eleftheriadis (UTH: University of Thessaly)H-Index: 19
#2Georgios Pissas (UTH: University of Thessaly)H-Index: 12
Last. Ioannis Stefanidis (UTH: University of Thessaly)H-Index: 28
view all 6 authors...
BACKGROUND: Glucotoxicity in renal tubular epithelial cells (RPTECs) contributes to the pathogenesis of diabetic nephropathy. Sodium-glucose cotransporter 2 (SGLT2) inhibitors may exert their renoprotective effect by preventing glucotoxicity. We tested whether the confirmed in capillary endothelial cells unifying model of glucotoxicity can be applied in RPTECs and the impact of dapagliflozin. METHODS: In primary human RPTECs cultured in normal or high glucose medium in the presence or not of dap...
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#1Pinar SoysalH-Index: 12
#2Chao Cao (WashU: Washington University in St. Louis)H-Index: 2
Last. Lee Smith (ARU: Anglia Ruskin University)H-Index: 20
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Increased nocturia episodes can be a clinical marker of poor health status. The present study aimed to evaluate patterns and temporal trends in nocturia and sociodemographic and lifestyle correlates in the US population. Participants, aged 20 years or older, were included in this repeated cross-sectional study. The National Health and Nutrition Examination Survey from 2005 to 2016 was used. Participants were asked “During the past 30 days, how many times per night did you most typically get up t...
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Kidney disease
Kidney
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Diabetes mellitus
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