Review paper
Epigenomic control of gonadotrophin‐releasing hormone neurone development and hypogonadotrophic hypogonadism
Abstract
Mammalian reproductive success depends on gonadotrophin‐releasing hormone (GnRH) neurones to stimulate gonadotrophin secretion from the anterior pituitary and activate gonadal steroidogenesis and gametogenesis. Genetic screening studies in patients diagnosed with Kallmann syndrome (KS), a congenital form of hypogonadotrophic hypogonadism (CHH), identified several causal mutations, including those in the fibroblast growth factor (FGF) system....
Paper Details
Title
Epigenomic control of gonadotrophin‐releasing hormone neurone development and hypogonadotrophic hypogonadism
Published Date
May 26, 2020
Volume
32
Issue
6
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