Review paper
Genome Topology Control of Antigen Receptor Gene Assembly
Abstract
The past decade has increased our understanding of how genome topology controls RAG endonuclease-mediated assembly of lymphocyte AgR genes. New technologies have illuminated how the large IgH, Igκ, TCRα/δ, and TCRβ loci fold into compact structures that place their numerous V gene segments in similar three-dimensional proximity to their distal recombination center composed of RAG-bound (D)J gene segments. Many studies have shown that CTCF and...
Paper Details
Title
Genome Topology Control of Antigen Receptor Gene Assembly
Published Date
May 15, 2020
Journal
Volume
204
Issue
10
Pages
2617 - 2626
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