Review paper
PARP goes the weasel! Emerging role of PARP inhibitors in acute leukemias
Abstract
Poly (ADP-ribose) polymerase (PARP) inhibitors, which induce synthetic lethality of BRCA mutant breast and ovarian cancers, are now under active exploration for treatment of acute leukemias, specifically acute myeloid leukemia (AML). Experimental data has revealed that DNA repair deficiencies similar to those found in BRCA mutant solid tumors function in malignant hematopoietic cells to enhance cell survival and promote therapy resistance....
Paper Details
Title
PARP goes the weasel! Emerging role of PARP inhibitors in acute leukemias
Published Date
Jan 1, 2021
Journal
Volume
45
Pages
100696 - 100696
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Notes
History