Dexmedetomidine alleviated sepsis‑induced myocardial ferroptosis and septic heart injury
Abstract
Cardiac dysfunction resulting from sepsis may cause significant morbidity and mortality, and ferroptosis plays a role in this pathology. Dexmedetomidine (Dex), a α2‑adrenergic receptor (α2‑AR) agonist exerts cardioprotective effects against septic heart dysfunction, but the exact mechanism is unknown. In the present study, sepsis was induced by cecal ligation and puncture (CLP) in male C57BL/6 mice. Dex and yohimbine hydrochloride (YOH), an...
Paper Details
Title
Dexmedetomidine alleviated sepsis‑induced myocardial ferroptosis and septic heart injury
Published Date
May 4, 2020
Journal
Volume
22
Issue
1
Pages
175 - 184
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