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Molecular Medicine Reports
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#1Gang Li (Zhengzhou University)
#2Menghan Xie (Zhengzhou University)
Last. Jinjian Yang (Zhengzhou University)H-Index: 5
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#1Lu Wang (Anhui University of Chinese Medicine)
#2Liran Zhu (Boston Children's Hospital)
Last. Guangliang Chen (Anhui University of Chinese Medicine)
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#1Wen Kang (WHU: Wuhan University)
#2Yue Cheng (WHU: Wuhan University)
Last. Liang ZhongH-Index: 1
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#1Fenghe Cui (Yangtze University)
#2Qian Zhou (Yangtze University)
Last. Haiyun Qian (Yangtze University)
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#1Xueping Xiang (Hunan Normal University)
#2Lesai LiH-Index: 1
Last. Yong Zhang (Hunan Normal University)H-Index: 2
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Angiogenesis plays an important role in the development and metastasis of tumors, and anti-angiogenesis agents are used to treat tumors. For example, the acute promyelocytic leukemia (APL) may be treated with arsenic trioxide. Angiogenesis in APL is a multistep dynamic equilibrium process coordinated by various angiogenic stimulators and inhibitors, which play key roles in the occurrence, progression and chemosensitivity of this disease. Our research group previously synthesized 7difluoromethyl5...
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#1Wei Yu (WMU: Wenzhou Medical College)
#2Peng-Bo Chen (SJTU: Shanghai Jiao Tong University)
Last. Xiao-Yun Pan (WMU: Wenzhou Medical College)
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MicroRNAs (miRNAs/miRs) are non-coding RNAs that regulate protein synthesis by targeting mRNAs for translational repression or degradation. Previous studies have reported that aberrant expression of miR744 may be involved in human osteosarcoma; however, the underlying mechanisms remain elusive. In the present study, the expression levels of miR744 and its downstream signals were determined by reverse transcriptionquantitative PCR and western blotting. Cell proliferation was assessed using the br...
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#1Xiaoyan Li (Academy of Medical Sciences, United Kingdom)
#2Jianying Xu (Academy of Medical Sciences, United Kingdom)
Last. Pingping Li (Shanxi Medical University)
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Adoptive transfer of bone marrowderived mesenchymal stem cells (BMSCs) significantly alleviates smokinginduced chronic obstructive pulmonary disease (COPD) in rats. Considering the critical roles of T cells during COPD development, the present study aimed to further identify the molecular mechanisms underlying the antiproliferative effect of BMSCs on splenic T cells isolated from rats following chronic exposure to nicotine. Splenic T cells were cocultured with rat BMSCs at various ratios and sub...
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#1Minzhen Deng (Guangzhou University of Chinese Medicine)H-Index: 1
#2Liping HuangH-Index: 1
Last. Xiaoqin Zhong (Guangzhou University of Chinese Medicine)H-Index: 1
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Alzheimer's disease (AD) is a common neurodegenerative disease in the elderly population. Autophagy is a wellknown regulator of neurodegenerative diseases and betaasarone has been discovered to have certain neuropharmacological effects. Thus, the present study aimed to analyze the potential effects of betaasarone in AD and its possible mechanism of action in relation to autophagy. The present study investigated the effects of betaasarone on the number of senile plaques and amyloid beta(Abeta)40,...
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#1Kazuyuki Ibaraki (Kobe University)H-Index: 2
#2Shinya Hayashi (Kobe University)H-Index: 14
Last. Ryosuke Kuroda (Kobe University)H-Index: 40
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Articular cartilage tissue has a poor healing potential, and when subjected to traumatic damage this tissue undergoes cartilage degeneration and osteoarthritis. The association between the regulation of cell cycle checkpoints and tissue regeneration has been previously investigated, and p21 was initially identified as a potent inhibitor of cell cycle progression. However, the effects of p21 defects on damaged tissue remain controversial. Therefore, the aim of the present study was to evaluate th...
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#1Lei Wu (Shihezi University)
#2Kai Chen (Shihezi University)
Last. Ketao Ma (Shihezi University)H-Index: 6
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Angiotensin II (AngII) serves an important inflammatory role in cardiovascular disease; it can induce macrophages to differentiate into the M1type, produce inflammatory cytokines and resist pathogen invasion, and can cause a certain degree of damage to the body. Previous studies have reported that connexin 43 (Cx43) and NFkappaB (p65) are involved in the AngIIinduced inflammatory pathways of macrophages; however, the mechanisms underlying the effects of Cx43 and NFkappaB (p65) on AngIIinduced ma...
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