Molecular structures and mechanisms of DNA break processing in mouse meiosis
Abstract
Exonucleolytic resection, critical to repair double-strand breaks (DSBs) by recombination, is not well understood, particularly in mammalian meiosis. Here, we define structures of resected DSBs in mouse spermatocytes genome-wide at nucleotide resolution. Resection tracts averaged 1100 nt, but with substantial fine-scale heterogeneity at individual hot spots. Surprisingly, EXO1 is not the major 5' → 3' exonuclease, but the DSB-responsive kinase...
Paper Details
Title
Molecular structures and mechanisms of DNA break processing in mouse meiosis
Published Date
Apr 30, 2020
Journal
Volume
34
Issue
11-12
Pages
806 - 818
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