Genes & Development
Papers 8157
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#1Yueh-Lin Tsai (Columbia University)
#2Tristan H. Coady (Columbia University)H-Index: 10
Last. James L. Manley (Columbia University)H-Index: 93
view all 8 authors...
Dysregulation of the DNA/RNA-binding protein FUS causes certain subtypes of ALS/FTD by largely unknown mechanisms. Recent evidence has shown that FUS toxic gain of function due either to mutations or to increased expression can disrupt critical cellular processes, including mitochondrial functions. Here, we demonstrate that in human cells overexpressing wild-type FUS or expressing mutant derivatives, the protein associates with multiple mRNAs, and these are enriched in mRNAs encoding mitochondri...
#1Fang Yang (UPenn: University of Pennsylvania)H-Index: 13
#1Fang Yang (UPenn: University of Pennsylvania)
Last. P. Jeremy Wang (UPenn: University of Pennsylvania)H-Index: 21
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DNA methylation is a major silencing mechanism of transposable elements (TEs). Here we report that TEX15, a testis-specific protein, is required for TE silencing. TEX15 is expressed in embryonic germ cells and functions during genome-wide epigenetic reprogramming. The Tex15 mutant exhibits DNA hypomethylation in TEs at a level similar to Mili and Dnmt3c but not Miwi2 mutants. TEX15 is associated with MILI in testis. As loss of Tex15 causes TE desilencing with intact piRNA production, our results...
#1Miki Jishage (Rockefeller University)H-Index: 2
#2Keiichi Ito (Rockefeller University)H-Index: 1
Last. Robert G. Roeder (Rockefeller University)H-Index: 6
view all 6 authors...
Liver regeneration and metabolism are highly interconnected. Here, we show that hepatocyte-specific ablation of RNA polymerase II (Pol II)-associated Gdown1 leads to down-regulation of highly expressed genes involved in plasma protein synthesis and metabolism, a concomitant cell cycle re-entry associated with induction of cell cycle-related genes (including cyclin D1), and up-regulation of p21 through activation of p53 signaling. In the absence of p53, Gdown1-deficient hepatocytes show a severe ...
#1Mukulika Ray (Brown University)H-Index: 1
#2Erica Larschan (Brown University)H-Index: 19
In this issue of Genes & Development, Lu and colleagues (pp. 663-677) have discovered a key new mechanism of alternative promoter choice that is involved in differentiation of spermatocytes. Promoter choice has strong potential as mechanism for differentiation of many different cell types.
#1Kimberly A. Rickman (Rockefeller University)H-Index: 8
#2Raymond J. Noonan (Rockefeller University)H-Index: 1
Last. Agata Smogorzewska (Rockefeller University)H-Index: 34
view all 10 authors...
DNA interstrand cross-links (ICLs) are a form of DNA damage that requires the interplay of a number of repair proteins including those of the Fanconi anemia (FA) and the homologous recombination (HR) pathways. Pathogenic variants in the essential gene BRCA2/FANCD1, when monoallelic, predispose to breast and ovarian cancer, and when biallelic, result in a severe subtype of Fanconi anemia. BRCA2 function in the FA pathway is attributed to its role as a mediator of the RAD51 recombinase in HR repai...
#1Felix Räsch (MPG: Max Planck Society)H-Index: 1
#2Ramona Weber (MPG: Max Planck Society)H-Index: 5
Last. Cátia Igreja (MPG: Max Planck Society)H-Index: 9
view all 4 authors...
Human 4E-T is an eIF4E-binding protein (4E-BP) present in processing (P)-bodies that represses translation and regulates decay of mRNAs destabilized by AU-rich elements and microRNAs (miRNAs). However, the underlying regulatory mechanisms are still unclear. Here, we show that upon mRNA binding 4E-T represses translation and promotes deadenylation via the recruitment of the CCR4-NOT deadenylase complex. The interaction with CCR4-NOT is mediated by previously uncharacterized sites in the middle re...
#1Rebecca Lamothe (University of California, Berkeley)
#2Lorenzo Costantino (University of California, Berkeley)H-Index: 3
Last. Douglas Koshland (University of California, Berkeley)H-Index: 54
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Condensin mediates chromosome condensation, which is essential for proper chromosome segregation during mitosis. Prior to anaphase of budding yeast, the ribosomal DNA (RDN) condenses to a thin loop that is distinct from the rest of the chromosomes. We provide evidence that the establishment and maintenance of this RDN condensation requires the regulation of condensin by Cdc5p (polo) kinase. We show that Cdc5p is recruited to the site of condensin binding in the RDN by cohesin, a complex related ...
#1Shuxi Qiao (Harvard University)H-Index: 10
#2Siang-Boon Koh (Harvard University)H-Index: 5
Last. Athena L. Chen (Harvard University)H-Index: 2
view all 16 authors...
Human cancers with activating RAS mutations are typically highly aggressive and treatment-refractory, yet RAS mutation itself is insufficient for tumorigenesis, due in part to profound metabolic stress induced by RAS activation. Here we show that loss of REDD1, a stress-induced metabolic regulator, is sufficient to reprogram lipid metabolism and drive progression of RAS mutant cancers. Redd1 deletion in genetically engineered mouse models (GEMMs) of KRAS-dependent pancreatic and lung adenocarcin...
#1Bishakha Mona (UTSW: University of Texas Southwestern Medical Center)H-Index: 2
#2Juan Villarreal (UTSW: University of Texas Southwestern Medical Center)
Last. Jane E. Johnson (UTSW: University of Texas Southwestern Medical Center)H-Index: 53
view all 6 authors...
Peripheral somatosensory input is modulated in the dorsal spinal cord by a network of excitatory and inhibitory interneurons. PTF1A is a transcription factor essential in dorsal neural tube progenitors for specification of these inhibitory neurons. Thus, mechanisms regulating Ptf1a expression are key for generating neuronal circuits underlying somatosensory behaviors. Mutations targeted to distinct cis-regulatory elements for Ptf1a in mice, tested the in vivo contribution of each element individ...
#1Jingyin Yue (UM: University of Miami)H-Index: 1
#2Roberto Vendramin (Katholieke Universiteit Leuven)H-Index: 3
Last. Lucia Speroni (UM: University of Miami)
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The emergence of drug resistance is a major obstacle for the success of targeted therapy in melanoma. Additionally, conventional chemotherapy has not been effective as drug-resistant cells escape lethal DNA damage effects by inducing growth arrest commonly referred to as cellular dormancy. We present a therapeutic strategy termed "targeted chemotherapy" by depleting protein phosphatase 2A (PP2A) or its inhibition using a small molecule inhibitor (1,10-phenanthroline-5,6-dione [phendione]) in dru...
Top fields of study
Molecular biology
Transcription factor
Cell biology