Abstract IA03: KRAS Q61H preferentially signals through the MAPK pathway in non-small cell lung cancer

RAS proteins are guanosine triphosphatases (GTPases) that function as binary switches cycling between inactive (GDP-bound) and active (GTP-bound) states. Activated RAS proteins bind RAS effectors including RAF kinases, PI3K, RalGDS, and others. Conversion from GDP to GTP is stimulated by guanine nucleotide exchange factors (GEFs) while conversion to the inactive GDP-bound form is mediated by GTPase activating proteins (GAPs). Mutations can alter...