Original paper

Melatonin directly binds and inhibits death‐associated protein kinase 1 function in Alzheimer’s disease

Volume: 69, Issue: 2
Published: May 27, 2020
Abstract
Death‐associated protein kinase 1 (DAPK1) is upregulated in the brains of human Alzheimer's disease (AD) patients compared with normal subjects, and aberrant DAPK1 regulation is implicated in the development of AD. However, little is known about whether and how DAPK1 function is regulated in AD. Here, we identified melatonin as a critical regulator of DAPK1 levels and function. Melatonin significantly decreases DAPK1 expression in a...
Paper Details
Title
Melatonin directly binds and inhibits death‐associated protein kinase 1 function in Alzheimer’s disease
Published Date
May 27, 2020
Volume
69
Issue
2
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