Review paper
Developmental Risks of Paternal Age in the Context of Adrenarche
Abstract
Paternal age at conception has the potential to alter the brain-endocrine axis during adrenarche (∼6-8 yo) for a number of reasons: 1) it is associated with sperm DNA alterations in regions involved in both brain and endocrine maturation; 2) significant shifts in adrenal hormones (dehydroepiandrosterone (DHEA), testosterone (T), androstenedione (A) and cortisol (C)) during middle childhood may increase the brain’s vulnerability to the impact of...
Paper Details
Title
Developmental Risks of Paternal Age in the Context of Adrenarche
Published Date
May 1, 2020
Journal
Volume
87
Issue
9
Pages
S270 - S270
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