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47-Year-Old Female with Left Upper Extremity Weakness and 28-Year-Old Male Motor Vehicle Accident Victim.

Published on May 1, 2020in Brain Pathology6.352
· DOI :10.1111/BPA.12836
Brian Le1
Estimated H-index: 1
(Reading Hospital),
Herman C. Lawson
Abstract
  • References (3)
  • Citations (0)
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References3
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#1Felix BehlingH-Index: 5
#2Alonso Barrantes-Freer (GAU: University of Göttingen)H-Index: 5
Last. Jens SchittenhelmH-Index: 32
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Background Treatment options for oncological diseases have been enhanced by the advent of targeted therapies. The point mutation of the BRAF gene at codon 600 (BRAF V600E) is found in several tumor entities and can be approached with selective inhibitory antibodies. The BRAF inhibitor vemurafenib has demonstrated clinical efficacy in patients with BRAF V600E-mutant melanoma brain metastases and in other cancer diseases. Therefore the BRAF V600E mutation is a highly interesting oncological target...
20 CitationsSource
#1Kazutaka Sugimoto (Yamaguchi University)H-Index: 6
#2Makoto Ideguchi (Yamaguchi University)H-Index: 12
Last. SuzukiMichiyasu (Yamaguchi University)H-Index: 30
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Epithelioid glioblastoma (GBM) and rhabdoid GBM are rare variants that are morphologically similar, but there is no consensus on the characteristics of each disease. These tumors have aggressive features of early recurrence and leptomeningeal dissemination and tend to develop in younger patients compared to typical GBM. The prognosis is normally worse than typical GBM, even with intensive chemoradiotherapy after surgical resection. Thus, accurate diagnosis and effective therapy for epithelioid/r...
14 CitationsSource
#1Fausto J. Rodriguez (Mayo Clinic)H-Index: 41
#2Bernd W. Scheithauer (Mayo Clinic)H-Index: 117
Last. Robert Brian Jenkins (Mayo Clinic)H-Index: 95
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BACKGROUND. Glioblastomas exhibit a remarkable tendency toward morphologic diversity. Although rare, pseudoepithelial components (adenoid or epithelioid) or true epithelial differentiation may occur, posing a significant diagnostic challenge. METHODS. Hematoxylin and eosin–stained slides were reviewed, and immunohistochemistry and fluorescence in situ hybridization were performed. RESULTS. The patients included 38 men and 20 women. The median age at diagnosis was 57 years (interquartile range [I...
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