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Brain Pathology
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#1Fatima Iqbal (University of Texas Health Science Center at Houston)H-Index: 1
#2Leomar Y. Ballester (University of Texas Health Science Center at Houston)H-Index: 4
Last. Meenakshi B. Bhattacharjee (University of Texas Health Science Center at Houston)H-Index: 19
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#1Diana G. Bohannon (EVMS: Eastern Virginia Medical School)
#2Yueying Wang (EVMS: Eastern Virginia Medical School)
Last. Woong-Ki Kim (EVMS: Eastern Virginia Medical School)H-Index: 17
view all 11 authors...
We previously showed that rhesus macaques neonatally infected with simian immunodeficiency virus (SIV) do not develop SIV encephalitis (SIVE) and maintain low brain viral loads despite having similar plasma viral loads compared to SIV-infected adults. We hypothesize that differences in myeloid cell populations that are the known target of SIV and HIV in the brain contribute to the lack of neonatal susceptibility to lentivirus-induced encephalitis. Using immunohistochemistry and immunofluorescenc...
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#1Marcos Devanir Silva da Costa (UNIFESP: Federal University of São Paulo)H-Index: 5
#2Maurício Panicio (UNIFESP: Federal University of São Paulo)H-Index: 2
Last. Sergio Cavalheiro (UNIFESP: Federal University of São Paulo)H-Index: 21
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#1Brent A. Orr (St. Jude Children's Research Hospital)H-Index: 24
Medulloblastoma (MB) is the most common CNS embryonal tumor. While the overall cure rate is around 70%, patients with high risk disease continue to have poor outcome and experience long term morbidity. Medulloblastoma is among the tumors for which diagnosis, risk stratification, and clinical management has shown the most rapid advancement. These advances are largely due to technological improvements in diagnosis and risk stratification which now integrate histomorphologic classification and mole...
1 CitationsSource
#1Martine F. Roussel (St. Jude Children's Research Hospital)H-Index: 79
#2Jennifer Stripay (St. Jude Children's Research Hospital)H-Index: 1
Mouse models of medulloblastoma have proven to be instrumental in understanding disease mechanisms, particularly the role of epigenetic and molecular drivers, and establishing appropriate preclinical pipelines. To date, our research community has developed murine models for all four groups of medulloblastoma, each of which will be critical for the identification and development of new therapeutic approaches. Approaches to modeling medulloblastoma range from genetic engineering with CRISPR/Cas9 o...
2 CitationsSource
#1Viktoria Ruf (LMU: Ludwig Maximilian University of Munich)H-Index: 3
#2Anne Schöler (DKFZ: German Cancer Research Center)H-Index: 2
Last. Ulrich Schüller (UHH: University of Hamburg)H-Index: 7
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#1Rahul Kumar (St. Jude Children's Research Hospital)H-Index: 1
#2Anthony P. Y. Liu (St. Jude Children's Research Hospital)H-Index: 4
Last. Paul A. Northcott (St. Jude Children's Research Hospital)H-Index: 63
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Medulloblastoma (MB) represents a spectrum of biologically and clinically distinct entities. Initially described histopathologically as a small, round blue cell tumor arising in the cerebellum, MB has emerged as a paradigm for molecular classification in cancer. Recent advances in genomic, transcriptomic and epigenomic profiling of MB have further refined molecular classification and complemented conventional histopathological diagnosis. Herein, we review the main clinical and molecular features...
1 CitationsSource
#1Muneera Fayyad (Khalifa University)H-Index: 1
#2Daniel Erskine (Newcastle University)H-Index: 8
Last. Christopher Morris (Newcastle University)H-Index: 59
view all 12 authors...
Aggregation of the protein alpha-synuclein (alpha-syn) into insoluble intracellular assemblies termed Lewy bodies (LBs) is thought to be a critical pathogenic event in LB diseases such as Parkinson's disease and dementia with LBs. In LB diseases, the majority of alpha-syn is phosphorylated at serine 129 (pS129), suggesting this is an important disease-related post-translational modification (PTM). However, PTMs do not typically occur in isolation, and phosphorylation at the proximal tyrosine 125...
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#2S. Leonard-Louis (University of Paris)H-Index: 1
Last. Yves Allenbach (University of Paris)H-Index: 21
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AIMS: Oedema of the limbs is uncommon in idiopathic inflammatory myopathies (IIM). The few reported cases have been associated with severe and refractory dermatomyositis (DM), sometimes in association with cancers. We aimed to determine if oedematous myositis is a homogeneous subtype based on clinical, serological and pathological features. METHODS: This is a retrospective observational study performed between 2008 and 2015 in the French national referral center for myositis. All adult patients ...
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