Original paper
Squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation
Abstract
A highly aggressive subset of pancreatic ductal adenocarcinomas undergo trans-differentiation into the squamous lineage during disease progression. Here, we investigated whether squamous trans-differentiation of human and mouse pancreatic cancer cells can influence the phenotype of non-neoplastic cells in the tumor microenvironment. Conditioned media experiments revealed that squamous pancreatic cancer cells secrete factors that recruit...
Paper Details
Title
Squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation
Published Date
Apr 24, 2020
Journal
Volume
9
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Notes
History