Cytosine base editors with minimized unguided DNA and RNA off-target events and high on-target activity
Abstract
Cytosine base editors (CBEs) enable efficient, programmable reversion of T•A to C•G point mutations in the human genome. Recently, cytosine base editors with rAPOBEC1 were reported to induce unguided cytosine deamination in genomic DNA and cellular RNA. Here we report eight next-generation CBEs (BE4 with either RrA3F [wt, F130L], AmAPOBEC1, SsAPOBEC3B [wt, R54Q], or PpAPOBEC1 [wt, H122A, R33A]) that display comparable DNA on-target editing...
Paper Details
Title
Cytosine base editors with minimized unguided DNA and RNA off-target events and high on-target activity
Published Date
Apr 28, 2020
Journal
Volume
11
Issue
1
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