Original paper
Targeting zonulin and intestinal epithelial barrier function to prevent onset of arthritis
Abstract
Gut microbial dysbiosis is associated with the development of autoimmune disease, but the mechanisms by which microbial dysbiosis affects the transition from asymptomatic autoimmunity to inflammatory disease are incompletely characterized. Here, we identify intestinal barrier integrity as an important checkpoint in translating autoimmunity to inflammation. Zonulin family peptide (zonulin), a potent regulator for intestinal tight junctions, is...
Paper Details
Title
Targeting zonulin and intestinal epithelial barrier function to prevent onset of arthritis
Published Date
Apr 24, 2020
Journal
Volume
11
Issue
1
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Notes
History