Absolute Quantification of Transcription Factors Reveals Principles of Gene Regulation in Erythropoiesis
Abstract
Dynamic cellular processes such as differentiation are driven by changes in the abundances of transcription factors (TFs). However, despite years of studies, our knowledge about the protein copy number of TFs in the nucleus is limited. Here, by determining the absolute abundances of 103 TFs and co-factors during the course of human erythropoiesis, we provide a dynamic and quantitative scale for TFs in the nucleus. Furthermore, we establish the...
Paper Details
Title
Absolute Quantification of Transcription Factors Reveals Principles of Gene Regulation in Erythropoiesis
Published Date
Jun 1, 2020
Journal
Volume
78
Issue
5
Pages
960 - 974.e11
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