Reducing Senescent Cell Burden in Aging and Disease

Accumulation of senescent cells is a fundamental aging process that contributes to age-onset disease, compromises health-span, and shortens life-span. Senescent cells have been cleared genetically in animal models and pharmacologically in animals and humans. Reduction in senescent cell burden can be accomplished pharmacologically by targeting antiapoptotic networks or SASP. Early, proof-of-principle pilot clinical studies on senolytic agents are...