Trends in Molecular Medicine
Papers 2031
1 page of 204 pages (2,031 results)
#1Xuan Zhang (Peking Union Medical College)H-Index: 32
#2Bei-di Chen (Peking Union Medical College)H-Index: 2
Last. Hao Li (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 2
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The pathogenesis of autoimmune diseases (AIDs) is not only attributed to genetic susceptibilities but also environmental factors, among which, disturbed gut microbiota has attracted increasing attention. Compositional and functional changes of gut microbiota have been reported in various AIDs, and increasing evidence suggests that disturbed gut microbiota contributes to their immunopathogenesis. The accepted mechanisms include abnormal microbial translocation, molecular mimicry, and dysregulatio...
#1Yurim Park (University of Oxford)
Last. Feng Cheng (THU: Tsinghua University)
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Abstract Emergence of new disease remains a critical parameter in human health and society. Advances in artificial intelligence (AI) allow for rapid processing and analysis of massive and complex data. In this forum article we review recent applications across disease prediction and drug development with a focus on the COVID-19 pandemic.
#1Norihito Uemura (UPenn: University of Pennsylvania)H-Index: 1
#2Maiko T Uemura (UPenn: University of Pennsylvania)H-Index: 1
Last. John Q. Trojanowski (UPenn: University of Pennsylvania)H-Index: 194
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The stereotypical spread of pathological protein inclusions and clinicopathological heterogeneity are well described in neurodegenerative diseases. Accumulating evidence suggests that the former can be attributed to consecutive cell-to-cell transmission of pathological proteins between anatomically connected brain regions, while the latter has been hypothesized to result from the spread of conformationally distinct pathological protein aggregates, or strains. These emerging concepts have dramati...
#1Danay Cibrian (UAM: Autonomous University of Madrid)H-Index: 8
#2Hortensia de la Fuente (UAM: Autonomous University of Madrid)H-Index: 23
Last. Francisco Sánchez-Madrid (UAM: Autonomous University of Madrid)H-Index: 91
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Keratinocytes and skin immune cells are actively metabolizing nutrients present in their microenvironment. This is particularly important in common chronic inflammatory skin diseases such as psoriasis and atopic dermatitis, characterized by hyperproliferation of keratinocytes and expansion of inflammatory cells, thus suggesting increased cell nutritional requirements. Proliferating inflammatory cells and keratinocytes express high levels of glucose transporter (GLUT)1, l -type amino acid transpo...
#1Cecilia Rocchi (Edin.: University of Edinburgh)
#2Elaine Emmerson (Edin.: University of Edinburgh)H-Index: 13
Permanent damage to the salivary glands and resulting hyposalivation and xerostomia have a substantial impact on patient health, quality of life, and healthcare costs. Currently, patients rely on lifelong treatments that alleviate the symptoms, but no long-term restorative solutions exist. Recent advances in adult stem cell enrichment and transplantation, bioengineering, and gene transfer have proved successful in rescuing salivary gland function in a number of animal models that reflect human d...
#1Zhengyu Jiang (Columbia University)H-Index: 13
#2Ruth A. White (Columbia University)H-Index: 2
Last. Timothy C. Wang (Columbia University)H-Index: 79
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The bulk of the pancreas primarily comprises long-lived acinar cells that are not considered a bona fide source for stem cells. However, certain acinar subpopulations have a repopulating capacity during regeneration, raising the hypothesis as to the presence of regenerative progenitor-like populations in the adult pancreas. Here, we describe recent discoveries based on fate-mapping techniques that support the existence of progenitor-like acinar subpopulations, including active progenitor-like ce...
#1Pasquale Gallina (UniFI: University of Florence)H-Index: 14
#2Berardino Porfirio (UniFI: University of Florence)H-Index: 18
Last. Francesco Lolli (UniFI: University of Florence)H-Index: 27
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#1Eric J. Nestler (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 157
#2Stephen G. Waxman (Yale University)H-Index: 114
What biological factors account for resilience to pain or to behavioral stress? Here, we discuss examples of cellular and molecular mechanisms within disparate parts of the nervous system as contributors to such resilience. In some especially well-studied humans, it is possible to identify particular neuronal cell types in the peripheral nervous system (PNS) and pinpoint specific genes that are major contributors to pain resilience. We also discuss more complex factors that operate within the ce...
#1Robert J. Pignolo (Mayo Clinic)H-Index: 31
#2João F. Passos (Mayo Clinic)H-Index: 29
Last. James L. Kirkland (Mayo Clinic)H-Index: 55
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Cellular senescence is a primary aging process and tumor suppressive mechanism characterized by irreversible growth arrest, apoptosis resistance, production of a senescence-associated secretory phenotype (SASP), mitochondrial dysfunction, and alterations in DNA and chromatin. In preclinical aging models, accumulation of senescent cells is associated with multiple chronic diseases and disorders, geriatric syndromes, multimorbidity, and accelerated aging phenotypes. In animals, genetic and pharmac...
#1Barbara Bedogni (UM: University of Miami)H-Index: 1
#2Ralf Paus (University of Manchester)H-Index: 93
Melanocyte stem cells (MeSCs), one candidate for the cellular origin of melanoma, reside in the bulge region of the hair follicle (HF), an immune-privileged tissue niche with impaired tumor immunosurveillance. Surprisingly, however, primary melanoma is only very rarely associated with HFs. Here, we explore the hypothesis that this profoundly immunoinhibitory signaling environment deprives both MeSCs and melanocytes of the anagen hair matrix of proinflammatory signals required for full oncogenic ...
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