Trends in Molecular Medicine
Papers 1998
1 page of 200 pages (1,998 results)
#1Sarah E. Lee (NIH: National Institutes of Health)
#2Monica Duran-Martinez (NIH: National Institutes of Health)
Last.Faycal Guedj (NIH: National Institutes of Health)H-Index: 14
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While preclinical studies have reported improvement of behavioral deficits in the Ts65Dn mouse model of Down syndrome (DS), translation to human clinical trials to improve cognition in individuals with DS has had a poor success record. Timing of the intervention, choice of animal models, strategy for drug selection, and lack of translational endpoints between animals and humans contributed to prior failures of human clinical trials. Here, we focus on in vitro cell models from humans with DS to i...
#1Siwen Wu (WMU: Wenzhou Medical College)H-Index: 1
#2Ming Yan (CPU: China Pharmaceutical University)H-Index: 13
Last.C. Yan Cheng (WMU: Wenzhou Medical College)H-Index: 69
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Spermatogenesis is supported by intricate crosstalk between Sertoli cells and germ cells including spermatogonia, spermatocytes, haploid spermatids, and spermatozoa, which takes place in the epithelium of seminiferous tubules. Sertoli cells, also known as ‘mother’ or ‘nurse’ cells, provide nutrients, paracrine factors, cytokines, and other biomolecules to support germ cell development. Sertoli cells facilitate the generation of several biologically active peptides, which include F5-, noncollagen...
1 CitationsSource
#1Robert E. Steinert (DSM)H-Index: 21
#2Yuan-Kun Lee (NUS: National University of Singapore)H-Index: 3
Last.Wilbert Sybesma (DSM)
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A main target in microbiome research is the understanding and ability to safely and effectively modulate the microbiome to improve health. Hereto, we discuss the role of vitamins in relation to the gut microbiome and present a rationale for the modulation of gut microbial communities via selected systemic and colon-targeted vitamin administration.
#1Juanita K. Jellyman (CPP: California State Polytechnic University, Pomona)H-Index: 12
Last.Dino A. Giussani (University of Cambridge)H-Index: 42
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The last decade has seen rapid advances in the understanding of the central role of glucocorticoids in preparing the fetus for life after birth. However, relative to other organ systems, maturation by glucocorticoids of the fetal cardiovascular system has been ignored. Here, we review the effects of glucocorticoids on fetal basal cardiovascular function and on the fetal cardiovascular defense responses to acute stress. This is important because glucocorticoid-driven maturational changes in fetal...
#1Zhao Zhang (University of Texas Health Science Center at Houston)H-Index: 5
#2Shengli Li (University of Texas Health Science Center at Houston)H-Index: 7
Last.Leng Han (University of Texas Health Science Center at Houston)H-Index: 36
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Spliceosomes comprise small nuclear (sn)RNAs and proteins. Through genome-wide analyses in large-scale tumor samples, recent studies by Shuai et al. , Suzuki et al. , and Inoue et al. have identified recurrent spliceosomal mutations that induced genome-wide splicing alterations of cancer-related genes to promote malignancy. These discoveries suggest novel RNA-based therapeutics in anticancer treatment.
#1Omar L. Kantidze (RAS: Russian Academy of Sciences)H-Index: 10
#2Katerina Gurova (Roswell Park Cancer Institute)H-Index: 24
Last.Sergey V. Razin (MSU: Moscow State University)H-Index: 34
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The role of 3D genome organization in the precise regulation of gene expression is well established. Accordingly, the mechanistic connections between 3D genome alterations and disease development are becoming increasingly apparent. This opinion article provides a snapshot of our current understanding of the 3D genome alterations associated with cancers. We discuss potential connections of the 3D genome and cancer transcriptional addiction phenomenon as well as molecular mechanisms of action of 3...
#1Sonja NeumeyerH-Index: 1
#2Gibran Hemani (Medical Research Council)H-Index: 33
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Large genome-wide association studies (GWAS) have identified loci that are associated with complex traits and diseases, but index variants are often not causal and reside in non-coding regions of the genome. To gain a better understanding of the relevant biological mechanisms, intermediate traits such as gene expression and protein levels are increasingly being investigated because these are likely mediators between genetic variants and disease outcome. Genetic variants associated with intermedi...
1 CitationsSource
#1Xiaozhen Dai (Chengdu Medical College)
#2Xiaoqing Yan (WMU: Wenzhou Medical College)H-Index: 9
Last.Yi Tan (University of Louisville)H-Index: 34
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Nuclear factor erythroid 2-related factor 2 (Nrf2) is ubiquitously expressed in most eukaryotic cells and functions to induce a broad range of cellular defenses against exogenous and endogenous stresses, including oxidants, xenobiotics, and excessive nutrient/metabolite supply. Because the production and fate of stem cells are often modulated by cellular redox and metabolic homeostasis, important roles of Nrf2 have emerged in the regulation of stem cell quiescence, survival, self-renewal, prolif...
#1Yelena Sargsyan (GAU: University of Göttingen)
#2Sven Thoms (GAU: University of Göttingen)H-Index: 17
Peroxisomes share extensive metabolic connections with other cell organelles. Membrane contact sites (MCSs) establish and maintain such interactions, and they are vital for organelle positioning and motility. In the past few years peroxisome interactions and MCSs with other cellular organelles have been explored extensively, resulting in the identification of new MCSs, the tethering molecules involved, and their functional characterization. Defective tethering and compartmental communication can...
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