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Trends in Molecular Medicine
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11.03
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Published on Jun 1, 2019in Trends in Molecular Medicine11.03
Karim Hnia (University of Toulouse), Tim Clausen42
Estimated H-index: 42
(Medical University of Vienna),
Christel Moog-Lutz2
Estimated H-index: 2
(University of Toulouse)
For long-lived contractile cells, such as striated muscle cells, maintaining proteome integrity is a challenging task. These cells require hundreds of components that must be properly synthesized, folded, and incorporated into the basic contractile unit, the sarcomere. Muscle protein quality control in cells is mainly guaranteed by the ubiquitin-proteasome system (UPS), the lysosome-autophagy system, and various molecular chaperones. Recent studies establish the concept of dedicated UPS in the r...
Published on 2019in Trends in Molecular Medicine11.03
Manuela Teresa Raimondi27
Estimated H-index: 27
(Polytechnic University of Milan),
Diego Albani22
Estimated H-index: 22
,
Carmen Giordano18
Estimated H-index: 18
(Polytechnic University of Milan)
After decades of research, the etiology of neurodegenerative disorders such as Alzheimer’s or Parkinson’s disease is still mostly unknown. Recent findings indicate that the microorganisms in the human gut might be involved in neurodegenerative pathways. Here, we discuss an innovative groundbreaking bioengineering approach that could make a difference in this intriguing scenario.
Published on May 1, 2019in Trends in Molecular Medicine11.03
Chiara F. Valori4
Estimated H-index: 4
,
Giulia Guidotti3
Estimated H-index: 3
+ 1 AuthorsDaniela Rossi25
Estimated H-index: 25
Astrocytes fulfil several functions that collectively contribute to maintain the optimal microenvironment for neuronal function and survival. The multiplicity and complexity of these activities clearly indicates that the correct performance of astrocytes is crucial for the physiological functioning of the nervous system, and its derangement may contribute to the occurrence and progression of many neurological disorders. Although rectifying astrocyte malfunction has successfully counteracted dise...
Published on Sep 1, 2019in Trends in Molecular Medicine11.03
Robert J. Harvey48
Estimated H-index: 48
(University of the Sunshine Coast)
Startle disease results from mutations in genes encoding inhibitory GlyR α1 and β subunits or the presynaptic glycine transporter GlyT2. However, the most effective therapies are benzodiazepines that potentiate inhibitory GABAAR function. A recent publication by Zou et al . adds further complexity by suggesting that dominant GlyR α1 mutants assemble into pre- and extrasynaptic GABAARs.
Published on Sep 1, 2019in Trends in Molecular Medicine11.03
Chi Zhou3
Estimated H-index: 3
(Tongji University),
Chenyu Zhu3
Estimated H-index: 3
(Tongji University),
Qi Liu15
Estimated H-index: 15
(Tongji University)
Cancer immunotherapy includes cancer vaccination, adoptive T cell transfer (ACT) with chimeric antigen receptor (CAR) T cells, and administration of tumor-infiltrating lymphocytes and immune-checkpoint blockade such as anti-CTLA4/anti-PD1 inhibitors that can directly or indirectly target tumor neoantigens and elicit a T cell response. Accurate, rapid, and cost-effective identification of neoantigens, however, is critical for successful immunotherapy. Here, we review computational issues for neoa...
Published on Sep 1, 2019in Trends in Molecular Medicine11.03
Geoffrey Van den Bergh (University of Antwerp), Britt Opdebeeck2
Estimated H-index: 2
(University of Antwerp)
+ 1 AuthorsAnja Verhulst18
Estimated H-index: 18
(University of Antwerp)
Arterial media calcification and arterial stiffness are independent predictors of cardiovascular mortality. Both processes reinforce one another, creating a vicious cycle in which transdifferentiation of endothelial cells and vascular smooth muscle cells play a central role. Physiological functioning of vascular smooth muscle cells in the arterial medial layer greatly depends on normal endothelial cell behavior. Endothelial or intimal layer cells are the primary sensors of pathological triggers ...
Published on Sep 1, 2019in Trends in Molecular Medicine11.03
Gary Thomas47
Estimated H-index: 47
(University of Pittsburgh),
Arthur L. Horwich62
Estimated H-index: 62
(Yale University)
In a recent paper by Dvela-Levitt et al. , chemical screening using an immunofluorescent assay identified a compound that caused removal of a dominant-inherited misfolded secretory protein, mucin1-frameshifted, from an intracellular location in immortalized renal epithelial cells of a patient affected with progressive medullary cystic kidney disease. This illustrates the power of chemical screening at the cellular level to address specific proteinopathies and the utility of such compounds to ill...
Published on Sep 1, 2019in Trends in Molecular Medicine11.03
Michael Abers (NIH: National Institutes of Health), Michail S. Lionakis32
Estimated H-index: 32
(NIH: National Institutes of Health),
Dimitrios P. Kontoyiannis79
Estimated H-index: 79
(University of Texas MD Anderson Cancer Center)
The mammalian immune system has evolved the capacity to detect and destroy tumor cells. Tumors utilize multiple strategies to evade host immune surveillance, including the induction of the checkpoint molecules cytotoxic T lymphocyte-associated protein 4 (CTLA-4) and programmed cell death protein 1 (PD-1) to suppress antitumor immunity. Pharmacologic blockade of these molecules with checkpoint inhibitors (CPIs) restores T cell function and prolongs survival in patients with various malignancies. ...
Published on Sep 1, 2019in Trends in Molecular Medicine11.03
Zhengqiu Zhou1
Estimated H-index: 1
(UK: University of Kentucky),
Grant L. Austin1
Estimated H-index: 1
(UK: University of Kentucky)
+ 2 AuthorsMatthew S. Gentry22
Estimated H-index: 22
(UK: University of Kentucky)
The use of antibodies as targeting molecules or cell-penetrating tools has emerged at the forefront of pharmaceutical research. Antibody-directed therapies in the form of antibody–drug conjugates, immune modulators, and antibody-directed enzyme prodrugs have been most extensively utilized as hematological, rheumatological, and oncological therapies, but recent developments are identifying additional applications of antibody-mediated delivery systems. A novel application of this technology is for...
Published on Jun 1, 2019in Trends in Molecular Medicine11.03
Lay Kodama1
Estimated H-index: 1
(UCSF: University of California, San Francisco),
Li Gan (UCSF: University of California, San Francisco)
Sex differences have been clinically documented in numerous neurodegenerative diseases and yet the reasons for these differences are not well understood. Recent studies have found that microglia, the innate immune cells of the central nervous system, are a key cell type involved in neurodegenerative diseases. This cell type displays sex differences in their expression profiles and function. Could these sex differences in microglia explain the sex differences seen in neurodegenerative diseases? H...
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