A hybrid of two major Blomia tropicalis allergens as an allergy vaccine candidate

Introduction Allergen‐specific immunotherapy (AIT) represents a curative approach for treating allergies. In the tropical and subtropical regions of the world, Blomia tropicalis (Blo t 5 and Blo t 21) is the likely dominant source of indoor allergens. Aim To generate a hypoallergenic Blo t 5/Blo t 21 hybrid molecule that can treat allergies caused by B tropicalis . Methods Using in silico design of B tropicalis hybrid proteins, we chose two...