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Clinical & Experimental Allergy
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#1Corrado PelaiaH-Index: 6
#2Claudia Crimi (University of Catania)H-Index: 9
Last. Nunzio Crimi (University of Catania)H-Index: 31
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BACKGROUND: Anti-interleukin-5 (IL-5) monoclonal antibodies can be used as add-on biological therapies in allergic and non allergic patients with severe eosinophilic asthma. However, within such a therapeutic context real-life investigations are lacking. OBJECTIVE: Therefore, the aim of the present observational study was to evaluate the effects of mepolizumab in allergic and non allergic subjects with severe eosinophilic asthma. METHODS: Relevant clinical, functional, laboratory, and pharmacoth...
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#1Eduardo Santos da Silva (UFBA: Federal University of Bahia)
#2Lorenz Aglas (University of Salzburg)H-Index: 4
Last. Peter Lackner (University of Salzburg)H-Index: 25
view all 15 authors...
INTRODUCTION: Allergen-specific immunotherapy (AIT) represents a curative approach for treating allergies. In the tropical and subtropical regions of the world, Blomia tropicalis (Blo t 5 and Blo t 21) is the likely dominant source of indoor allergens. AIM: To generate a hypoallergenic Blo t 5/Blo t 21 hybrid molecule that can treat allergies caused by B. tropicalis. METHODS: Using in silico design of B. tropicalis hybrid proteins, we chose two hybrid proteins for heterologous expression. Wild-t...
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#1Mahmudur Rahman (SCU: Southern Cross University)H-Index: 6
#2Ramil Ramil (SCU: Southern Cross University)
Last. Bronwyn J. Barkla (SCU: Southern Cross University)H-Index: 25
view all 6 authors...
BACKGROUND: Brassica rapeseed crops contain high concentrations of oil in the seed. The remaining meal, following oil extraction, has a high protein-content, but is of low value due to the presence of high amounts of napin seed storage proteins. These 2S albumin-like proteins are difficult to digest and have been identified as major allergens in humans. OBJECTIVE: To comprehensively characterise the napin gene (NG) family in Brassica rapa and to gain an understanding of the structural basis of a...
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#1Michael Fricker (National Health and Medical Research Council)H-Index: 17
#2Ling Qin (University of Newcastle)H-Index: 1
Last. Peter G. GibsonH-Index: 83
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BACKGROUND: Mast cells (MCs) are innate immune cells that regulate atopic and non-atopic inflammation in the airways. MCs play a critical role in the pathogenesis of asthma, yet their relationship to airway and systemic inflammation and clinical characteristics of asthma is poorly understood. OBJECTIVE: To quantify MCs in induced sputum samples and understand their relationship to airway and circulatory immune cells, and clinical variables in asthma. METHODS: We employed flow cytometry of sputum...
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#1Mirjana Turkalj (UNIOS: Josip Juraj Strossmayer University of Osijek)H-Index: 7
#1Mirjana Turkalj (UNIOS: Josip Juraj Strossmayer University of Osijek)
Last. Adnan Custovic (NIH: National Institutes of Health)H-Index: 74
view all 10 authors...
BACKGROUND: Treatment of drinking water may decrease microbial exposure. OBJECTIVE: To investigate whether bacterial load in drinking water is associated with altered risk of allergic diseases. METHODS: We recruited 1,110 schoolchildren aged 6-16 years between 2011 and 2013 in Pozega-Slavonia County in Croatia, where we capitalized on a natural experiment whereby individuals receive drinking water through public mains supply or individual wells. We obtained data on microbial content of drinking ...
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#1Samuel T. Mindaye (Silver Spring Networks)H-Index: 2
#2Natalie A. David (Silver Spring Networks)H-Index: 1
Last. Jay E. Slater (Silver Spring Networks)H-Index: 15
view all 7 authors...
BACKGROUND: Allergen extracts are the primary tool for diagnosis and treatment of allergic diseases. In the United States, most allergen extracts are non-standardized. More sophisticated analytical approaches are needed to characterize these products and enable manufacturers and regulators to better determine potency. OBJECTIVE: To expand the multiple reaction monitoring (MRM) assay for an in-depth characterization of German cockroach (GCr; Blattella germanica) allergen extracts. METHODS: We app...
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#1Collin Brooks (Massey University)H-Index: 13
#2T. Slater (Massey University)H-Index: 15
Last. Jeroen Douwes (Massey University)H-Index: 53
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BACKGROUND: Cleaning is associated with an increased risk of asthma symptoms, but few studies have measured functional characteristics of airway disease in cleaners. AIMS: To assess and characterise respiratory symptoms and lung function in professional cleaners, and determine potential risk factors for adverse respiratory outcomes. METHODS: Symptoms, pre/post-bronchodilator lung function, atopy, and cleaning exposures were assessed in 425 cleaners and 281 reference workers in Wellington, New Ze...
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