Original paper
PNOCARC Neurons Promote Hyperphagia and Obesity upon High-Fat-Diet Feeding
Abstract
Calorie-rich diets induce hyperphagia and promote obesity, although the underlying mechanisms remain poorly defined. We find that short-term high-fat-diet (HFD) feeding of mice activates prepronociceptin (PNOC)-expressing neurons in the arcuate nucleus of the hypothalamus (ARC). PNOCARC neurons represent a previously unrecognized GABAergic population of ARC neurons distinct from well-defined feeding regulatory AgRP or POMC neurons. PNOCARC...
Paper Details
Title
PNOCARC Neurons Promote Hyperphagia and Obesity upon High-Fat-Diet Feeding
Published Date
Jun 1, 2020
Journal
Volume
106
Issue
6
Pages
1009 - 1025.e10
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Notes
History