Sirt6 in pro-opiomelanocortin neurons controls energy metabolism by modulating leptin signaling

Sirt6 is an essential regulator of energy metabolism in multiple peripheral tissues. However, the direct role of Sirt6 in the hypothalamus, specifically pro-opiomelanocortin (POMC) neurons, controlling energy balance has not been established. Here, we aimed to determine the role of Sirt6 in hypothalamic POMC neurons in the regulation of energy balance and the underlying mechanisms. For overexpression studies, the hypothalamic arcuate nucleus...