Molecular metabolism
Papers 887
1 page of 89 pages (887 results)
#1Katarina Klepac (University of Bonn)H-Index: 2
#2JuHee Yang (University of Bonn)
Last.Alexander Pfeifer (University of Bonn)H-Index: 53
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Abstract Objective Recruitment of brown adipose tissue (BAT) is a potential new strategy for increasing energy expenditure (EE) to treat obesity. G protein–coupled receptors (GPCRs) represent promising targets to activate BAT, as they are the major regulators of BAT biological function. To identify new regulators of GPCR signaling in BAT, we studied the role of Regulator of G protein Signaling 2 (RGS2) in brown adipocytes and BAT. Methods We combined pharmacological and genetic tools to investig...
#1Mostafa BakhtiH-Index: 7
Last.Heiko LickertH-Index: 27
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Abstract Objective Translation of basic research from bench-to-bedside relies on a better understanding of similarities and differences between mouse and human cell biology, tissue formation, and organogenesis. Thus, establishing ex vivo modeling systems of mouse and human pancreas development will help not only to understand evolutionary conserved mechanisms of differentiation and morphogenesis but also to understand pathomechanisms of disease and design strategies for tissue engineering. Metho...
#2Brian A. DrozH-Index: 2
Last.Ricardo J. SammsH-Index: 8
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Abstract Objective Fibroblast growth factor 19 (FGF19) is a post-prandial hormone which plays diverse roles in the regulation of bile acid, glucose, and lipid metabolism. Administration of FGF19 to obese/diabetic mice lowers body weight, improves insulin sensitivity, and enhances glycemic control. The primary target organ of FGF19 is the liver, where it regulates bile acid homeostasis in response to nutrient absorption. In contrast, the broader pharmacologic actions of FGF19 are proposed to be d...
#2Magali Joffraud (Nestlé)H-Index: 5
Last.Carles Cantó (EPFL: École Polytechnique Fédérale de Lausanne)H-Index: 35
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Abstract Objective A decay in intracellular NAD+ levels is one of the hallmarks of physiological decline in normal tissue functions. Accordingly, dietary supplementation with NAD+ precursors can prevent, alleviate, or even reverse multiple metabolic complications and age-related disorders in diverse model organisms. Within the constellation of NAD+ precursors, nicotinamide riboside (NR) has gained attention due to its potent NAD+ biosynthetic effects in vivo while lacking adverse clinical effect...
#1Karthickeyan Chella Krishnan (UCLA: University of California, Los Angeles)H-Index: 6
#2Simon Sabir (UCLA: University of California, Los Angeles)H-Index: 2
Last.Aldons J. Lusis (UCLA: University of California, Los Angeles)H-Index: 113
view all 19 authors...
Abstract Objective Lipocalin-2 (LCN2) is a secreted protein involved in innate immunity and has also been associated with several cardiometabolic traits in both mouse and human studies. However, the causal relationship of LCN2 to these traits is unclear, and most studies have examined only males. Methods Using adeno-associated viral vectors we expressed LCN2 in either adipose or liver in a tissue specific manner on the background of a whole-body Lcn2 knockout or wildtype mice. Metabolic phenotyp...
#1Daiane Engel (UFSC: Universidade Federal de Santa Catarina)H-Index: 8
#2Anna N. Grzyb (TUD: Dresden University of Technology)H-Index: 1
Last.Andreza Fabro de Bem (UFSC: Universidade Federal de Santa Catarina)H-Index: 22
view all 8 authors...
Abstract Objective In familial hypercholesterolemia (FH), mutations in the low-density lipoprotein (LDL) receptor (LDLr) gene result in increased plasma LDL cholesterol. Clinical and preclinical studies have revealed an association between FH and hippocampus-related memory and mood impairment. We here asked whether hippocampal pathology in FH might be a consequence of compromised adult hippocampal neurogenesis. Methods We evaluated hippocampus-dependent behavior and neurogenesis in adult C57BL/6...
#1Christie M. Penniman (Roy J. and Lucille A. Carver College of Medicine)H-Index: 1
#2Pablo A. Suarez Beltran (Roy J. and Lucille A. Carver College of Medicine)H-Index: 1
Last.Brian T. O’Neill (Roy J. and Lucille A. Carver College of Medicine)H-Index: 23
view all 9 authors...
Abstract Objective Gender influences obesity-related complications, including diabetes. Females are more protected from insulin resistance after diet-induced obesity, which may be related to fat accumulation and muscle insulin sensitivity. FoxOs regulate muscle atrophy and are targets of insulin action, but their role in muscle insulin sensitivity and mitochondrial metabolism is unknown. Methods We measured muscle insulin signaling, mitochondrial energetics, and metabolic responses to a high-fat...
#1Richard Cheng-An Chang (A&M: Texas A&M University)H-Index: 6
#2Kara N. Thomas (A&M: Texas A&M University)
Last.C Michael Golding. (A&M: Texas A&M University)
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Abstract Objectives Paternally inherited alterations in epigenetic programming are emerging as relevant factors in numerous disease states, including the growth and metabolic defects observed in fetal alcohol spectrum disorders. In rodents, chronic paternal alcohol use induces fetal growth restriction, as well as sex-specific alterations in insulin signaling and lipid homeostasis in the offspring. Based on previous studies, we hypothesized that the observed metabolic irregularities are the conse...
#1Sophie Trefely (Drexel University)H-Index: 8
#2Joyce Liu (UPenn: University of Pennsylvania)
Last.Nathaniel W. Snyder (Drexel University)H-Index: 20
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Abstract Objective The dynamic regulation of metabolic pathways can be monitored by stable isotope tracing. Yet, many metabolites are part of distinct processes within different subcellular compartments. Standard isotope tracing experiments relying on analyses in whole cells may not accurately reflect compartmentalized metabolic processes. Analysis of compartmentalized metabolism and the dynamic interplay between compartments can potentially be achieved by stable isotope tracing followed by subc...
#1Timo D. MüllerH-Index: 32
#2Brian Finan (Novo Nordisk)H-Index: 6
Last.Matthias H. Tschöp (TUM: Technische Universität München)H-Index: 78
view all 25 authors...
Abstract Background The glucagon-like peptide-1 (GLP-1) is a multifaceted hormone with broad pharmacological potential. Among the numerous metabolic effects of GLP-1 are the glucose-dependent stimulation of insulin secretion, decrease of gastric emptying, inhibition of food intake, increase of natriuresis and diuresis, and modulation of rodent β-cell proliferation. GLP-1 also has cardio- and neuroprotective effects, decreases inflammation and apoptosis, and has implications for learning and memo...
Top fields of study
Adipose tissue
Insulin resistance