Molecular metabolism
Papers 869
1 page of 87 pages (869 results)
Published on Dec 1, 2019in Molecular metabolism6.18
Daiane Engel8
Estimated H-index: 8
(UFSC: Universidade Federal de Santa Catarina),
Anna N Grzyb1
Estimated H-index: 1
(TUD: Dresden University of Technology)
+ 5 AuthorsAndreza Fabro de Bem20
Estimated H-index: 20
(UFSC: Universidade Federal de Santa Catarina)
Abstract Objective In familial hypercholesterolemia (FH), mutations in the low-density lipoprotein (LDL) receptor (LDLr) gene result in increased plasma LDL cholesterol. Clinical and preclinical studies have revealed an association between FH and hippocampus-related memory and mood impairment. We here asked whether hippocampal pathology in FH might be a consequence of compromised adult hippocampal neurogenesis. Methods We evaluated hippocampus-dependent behavior and neurogenesis in adult C57BL/6...
Published on 2019in Molecular metabolism6.18
Carl Beuchel (Leipzig University), Susen Becker23
Estimated H-index: 23
(Leipzig University)
+ 7 AuthorsJoachim Thiery52
Estimated H-index: 52
(Leipzig University)
Abstract Objective Human blood metabolites are influenced by a number of lifestyle and environmental factors. Identification of these factors and the proper quantification of their relevance provides insights into human biological and metabolic disease processes, is key for standardized translation of metabolite biomarkers into clinical applications, and is a prerequisite for comparability of data between studies. However, so far only limited data exist from large and well-phenotyped human cohor...
Published on Aug 1, 2019in Molecular metabolism6.18
Marie Mortreux , Ewout Foppen15
Estimated H-index: 15
+ 13 AuthorsFabrizio Andreelli32
Estimated H-index: 32
Abstract Objective Prokineticin 2 (PROK2) is a hypothalamic neuropeptide that plays a critical role in the rhythmicity of physiological functions and inhibits food intake. PROK2 is also expressed in the main olfactory bulb (MOB) as an essential factor for neuro-and morphogenesis. Since the MOB was shown to be strongly involved in eating behavior, we hypothesized that PROK2 could be a new target in the regulation of food intake and energy homeostasis, through its effects in the MOB. We also asked...
Published on Nov 1, 2019in Molecular metabolism6.18
Astrid Johannesson Hjelholt (Aarhus University Hospital), Kevin Y. Lee24
Estimated H-index: 24
(OU: Ohio University)
+ 5 AuthorsJens Otto Lunde Jørgensen67
Estimated H-index: 67
(Aarhus University Hospital)
Abstract Objective Growth hormone (GH) stimulates lipolysis, but the underlying mechanisms remain incompletely understood. We examined the effect of GH on the expression of lipolytic regulators in adipose tissue (AT). Methods In a randomized, placebo-controlled, cross-over study, nine men were examined after injection of 1) a GH bolus and 2) a GH-receptor antagonist (pegvisomant) followed by four AT biopsies. In a second study, eight men were examined in a 2 × 2 factorial design including GH inf...
Published on Nov 1, 2019in Molecular metabolism6.18
Lawrence Billing4
Estimated H-index: 4
(University of Cambridge),
Pierre Larraufie7
Estimated H-index: 7
(University of Cambridge)
+ 8 AuthorsFiona M. Gribble60
Estimated H-index: 60
(University of Cambridge)
Abstract Objective Enteroendocrine cells (EECs) of the large intestine, found scattered in the epithelial layer, are known to express different hormones, with at least partial co-expression of different hormones in the same cell. Here we aimed to categorize colonic EECs and to identify possible targets for selective recruitment of hormones. Methods Single cell RNA-sequencing of sorted enteroendocrine cells, using NeuroD1-Cre x Rosa26-EYFP mice, was used to cluster EECs from the colon and rectum ...
Published on Nov 1, 2019in Molecular metabolism6.18
Melissa J. S. Chee12
Estimated H-index: 12
(Carleton University),
Alex J. Hebert1
Estimated H-index: 1
(Carleton University)
+ 3 AuthorsEleftheria Maratos-Flier58
Estimated H-index: 58
(BIDMC: Beth Israel Deaconess Medical Center)
Abstract Objective Melanin-concentrating hormone (MCH) plays a key role in regulating energy balance. MCH acts via its receptor MCHR1, and MCHR1 deletion increases energy expenditure and locomotor activity, which is associated with a hyperdopaminergic state. Since MCHR1 expression is widespread, the neurons supporting the effects of MCH on energy expenditure are not clearly defined. There is a high density of MCHR1 neurons in the striatum, and these neurons are known to be GABAergic. We thus det...
Published on 2019in Molecular metabolism6.18
Beatriz Alvez Guerra8
Estimated H-index: 8
(UNIFESP: Federal University of São Paulo),
Bruna B. Brandão2
Estimated H-index: 2
(UNIFESP: Federal University of São Paulo)
+ 7 AuthorsBeatriz A. Castilho18
Estimated H-index: 18
(UNIFESP: Federal University of São Paulo)
Abstract Objective Dietary restriction (DR) improves health and prolongs lifespan in part by upregulating type III endoribonuclease DICER in adipose tissue. In this study, we aimed to specifically test which missing dietary component was responsible for DICER upregulation. Methods We performed a nutrient screen in mouse preadipocytes and validated the results in vivo using different kinds of dietary interventions in wild type or genetically modified mice and worms, also testing the requirement o...
Published on Aug 1, 2019in Molecular metabolism6.18
Lukas Maurer5
Estimated H-index: 5
Knut Mai23
Estimated H-index: 23
+ 3 AuthorsJoachim Spranger44
Estimated H-index: 44
Abstract Objectives This study evaluated the impact of the interaction between the anorexigenic incretin hormone glucagon-like peptide-1 (GLP-1) and reward-related brain activity in the dorsolateral prefrontal cortex (DLPFC), a key area of behavioral control, on future weight loss in obese individuals. Methods We performed a weight loss-weight maintenance intervention study over 27 months. We applied an fMRI food-cue reactivity paradigm during which the participants were passively exposed to foo...
Published on Nov 1, 2019in Molecular metabolism6.18
Yoon Keun Cho , Yeonho Son + 8 AuthorsJames G. Granneman42
Estimated H-index: 42
Abstract Objective This study investigated the role of microRNAs generated from adipose tissue macrophages (ATMs) during adipose tissue remodeling induced by pharmacological and nutritional stimuli. Methods Macrophage-specific Dicer knockout (KO) mice were used to determine the roles of microRNA generated in macrophages in adipose tissue remodeling induced by the β3-adrenergic receptor agonist CL316,243 (CL). RNA-seq was performed to characterize microRNA and mRNA expression profiles in isolated...
Published on Nov 1, 2019in Molecular metabolism6.18
Emilio P. Mottillo15
Estimated H-index: 15
(WSU: Wayne State University),
Huamei Zhang3
Estimated H-index: 3
(WSU: Wayne State University)
+ 2 AuthorsJames G. Granneman42
Estimated H-index: 42
(WSU: Wayne State University)
Abstract Objective Fatty acids are important for biological function; however, in excess, they can cause metabolic dysregulation. Methods to image and detect fatty acids in real time are lacking. Therefore, the current study examined the dynamics of fatty acid trafficking and signaling utilizing novel fluorescent and luminescent approaches. Methods We generated fluorescent and luminescent-based genetically-encoded sensors based upon the ligand-dependent interaction between PPARα and SRC-1 to ima...