Loading and Controlled Release of Poorly Water-Soluble Drug Telmisartan from Porous Silicon Microparticles

To prepare porous silicon microparticles by electrochemical etching process and study telmisartan loading and release kinetics to develop controlled drug delivery system. A 50 mA/cm2 of current density was applied for 180 s in HF:ethanol (2:4) solution for the etching of silicon wafer. The silicon film was fractured by probe sonication at 20 kHz of frequency and 750 W powers for 120 s to make the micro-sized particles. Drug-loading was carried...