Bioprocess Technologies that Preserve the Quality of iPSCs

Maintenance of pluripotent status and self-renewal capability are essential for the production of clinical-grade iPSCs for cell therapies. Media and matrix formulations and matrices have evolved through consideration of the signaling pathways that help to sustain pluripotency in iPSC lines and overall process scalability. Matrix- and feeder-free iPSC suspension culture systems overcome the limited scalability of static matrices while supporting...