Dysregulation of nuclear factor erythroid 2-related factor 2 signaling and activation of fibrogenic pathways in hearts of high fat diet-fed rats

High fat diet (HFD)-induced obesity adversely affects cardiac outcomes; however the effect of HFD consumption on myocardial remodeling and the underlying mechanisms are still elusive. This study aimed to examine the histological and molecular changes in cardiac tissue of HFD-fed rats. Eight-week old male Wistar rats were fed either HFD or normal chow diet for 16 weeks and then assessed for changes in metabolic and cardiac homeostasis (n = 10...