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Molecular Biology Reports
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Papers 7520
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#1Qi-Xiang Lu (ZSTU: Zhejiang Sci-Tech University)
#2Jing Gao (ZSTU: Zhejiang Sci-Tech University)
Last. Pan Li (Ministry of Education)H-Index: 8
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The lily-of-the-valley Convallaria (Asparagaceae) consists of three herbaceous perennial species. The plants are commonly found in northern hemisphere, and are best-known for their ornamental and pharmaceutical value. In order to assess the genetic structure, diversity and demographic history of Convallaria species, 19 novel microsatellite markers were developed based on transcriptome data of C. keiskei. Polymorphism and cross-amplification of the markers were tested in three populations of C. k...
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#1Wen JuH-Index: 2
Last. Lingyu ZengH-Index: 13
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Murine bone marrow-derived macrophages (M0) and M1- and M2-polarized macrophages are being widely used as a laboratory model for polarized macrophages related molecular mechanism analysis. Gene expression analysis based on reference gene normalization using RT-qPCR was a powerful way to explore the molecular mechanism. But little is known about reference genes in these cell models. So, the goal of this study was to identify reference genes in these types of macrophages. Candidate reference genes...
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#1Donghui Liu (CPU: China Pharmaceutical University)
#2Grigori Y. Rychkov (University of Adelaide)H-Index: 31
Last. Xin-Fu Zhou (UniSA: University of South Australia)H-Index: 44
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Neural cell transplantation is an effective way for treatment of neurological diseases. However, the absence of transplantable human neurons remains a barrier for clinical therapies. Human urine-derived cells, namely renal cells and urine stem cells, have become a good source of cells for reprogramming or trans-differentiation research. Here, we show that human urine-derived cells can be partially converted into neuron-like cells by applying a cocktail of small molecules. Gene expression analysi...
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#1Rajesh Ghangal (JNU: Jawaharlal Nehru University)
#2Mohan Singh Rajkumar (JNU: Jawaharlal Nehru University)H-Index: 3
Last. Mukesh K. Jain (JNU: Jawaharlal Nehru University)H-Index: 66
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Glutathione S-transferases (GSTs) are multifunctional proteins that help in oxidative stress metabolism and detoxification of xenobiotic compounds. Studies pertaining to GST gene family have been undertaken in various plant species, however no information is available with respect to GST genes in chickpea. In the current study, we identified a total of 51 GST encoding genes in chickpea (CaGST) genome. Phylogenetic analysis revealed that GST gene family can be divided into eleven distinct classes...
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RCCX haplotypes with two copies of the CYP21A2 gene and one copy of the CYP21A1P pseudogene have been widely described in different populations. In most cases, the CYP21A2-like gene downstream of the TNXA gene showed a wild-type sequence or the c.293-13A/C > G variant while the CYP21A2 gene next to TNXB carried the p.(Gln319Ter) variant. Here is the discovery of a novel rare CYP21A2 haplotypes detected in an Italian patient with Non Classical Congenital Adrenal Hyperplasia (NC-CAH). The molecula...
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#1Maki Yoshikawa (Rits: Ritsumeikan University)
#2Masashi Hosokawa (Hokkaido University)H-Index: 42
Last. Takeshi Hashimoto (Rits: Ritsumeikan University)H-Index: 14
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The combination of sarcopenia and obesity (i.e., sarcopenic obesity) is more strongly associated with disability and metabolic/cardiovascular diseases than obesity or sarcopenia alone. Therefore, countermeasures that simultaneously suppress fat gain and muscle atrophy to prevent an increase in sarcopenic obesity are warranted. The aim of this study was to investigate the simultaneous effects of fucoxanthinol (FXOH) on fat loss in mature adipocytes and the inhibition of atrophy and loss in myotub...
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#1P. Riedlova (University of Ostrava)
#2J. Janoutova (Palacký University, Olomouc)
Last. B. Hermanova (University of Ostrava)
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Breast cancer is currently the most common form of malignant tumour in womenboth in the Czech Republic and in most countries of the western world, and its incidence is constantly increasing. Many risk factors are known to play a major role in the development of this form of cancer. One of them is genetics, especially the BRCA1/2 genes. A higher risk of ovarian cancer is also associated with these genes. With the development of laboratory diagnostics massive parallel sequencing methods (NGS) are ...
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#1Mai M. Al-Oqail (KSU: King Saud University)H-Index: 10
#2Nida N. Farshori (KSU: King Saud University)H-Index: 10
Last. Abdulaziz A. Al-Khedhairy (KSU: King Saud University)H-Index: 31
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A number of liver diseases are known to be caused by oxidative stress. Petroselinum sativum (P. sativum; parsley) is popular for its anti-inflammatory, antimicrobial, anticancer, antioxidant and antidiabetic activities. However, till date the hepatoprotective potential of chloroform extract of P. sativum (PSA) on hydrogen peroxide (H2O2) induced cytotoxicity and oxidative stress in human liver (HepG2) cells have not been studied. Therefore, this study was framed to evaluate whether the levels of...
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#1Mohammad Mahdi Forghanifard (IAU: Islamic Azad University)H-Index: 13
#2Shirin Azaraz (MUMS: Mashhad University of Medical Sciences)
Last. Mohammad Reza Abbaszadegan (MUMS: Mashhad University of Medical Sciences)H-Index: 22
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Mastermind-like 1 (MAML1) is the main transcriptional co-activator of Notch signaling pathway. It plays essential roles in several pathways including MEF2C, p53, Nf-кB and Wnt/β-catenin. TWIST1 is known as a regulator of epithelial mesenchymal transition (EMT), which is considered as a primary step in promotion of tumor cell metastasis. Since concomitant expression of these genes was observed in tumors, our aim in this study was to elucidate the linkage between MAML1 and TWIST1 co-overexpression...
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#1Yujuan Wang (JLU: Jilin University)
#2Han Xiao (JLU: Jilin University)
Last. Junling Yang (JLU: Jilin University)H-Index: 5
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Idiopathic pulmonary fibrosis (IPF) is an agnogenic, rare, and lethal disease, with high mortality and poor prognosis and a median survival time as short as 3 to 5 years after diagnosis. No effective therapeutic drugs are still not available not only in clinical practice, but also in preclinical phases. To better and deeper understand pulmonary fibrosis will provide more effective strategies for therapy. Mounting evidence suggests that noncoding RNAs (ncRNAs) and their interactions may contribut...
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