Original paper

Smooth Muscle Cell Reprogramming in Aortic Aneurysms

Volume: 26, Issue: 4, Pages: 542 - 557.e11
Published: Apr 1, 2020
Abstract
The etiology of aortic aneurysms is poorly understood, but it is associated with atherosclerosis, hypercholesterolemia, and abnormal transforming growth factor β (TGF-β) signaling in smooth muscle. Here, we investigated the interactions between these different factors in aortic aneurysm development and identified a key role for smooth muscle cell (SMC) reprogramming into a mesenchymal stem cell (MSC)-like state. SMC-specific ablation of TGF-β...
Paper Details
Title
Smooth Muscle Cell Reprogramming in Aortic Aneurysms
Published Date
Apr 1, 2020
Volume
26
Issue
4
Pages
542 - 557.e11
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