Identifying the immune interactions underlying HLA class I disease associations
Abstract
Variation in the risk and severity of many autoimmune diseases, malignancies and infections is strongly associated with polymorphisms at the HLA class I loci. These genetic associations provide a powerful opportunity for understanding the etiology of human disease. HLA class I associations are often interpreted in the light of 'protective' or 'detrimental' CD8+ T cell responses which are restricted by the host HLA class I allotype. However,...
Paper Details
Title
Identifying the immune interactions underlying HLA class I disease associations
Published Date
Apr 2, 2020
Journal
Volume
9
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Notes
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