Preparation and Evaluation of BDNF Composite Conduits for Regeneration of Sciatic Nerve Defect in Rats

The treatment of peripheral nerve injury is still a challenge. The present study was aimed to fabricate a composite nerve conduit containing slow-released brain-derived neurotrophic factor (BDNF) and evaluate its therapeutic effects on peripheral nerve defect. BDNF and polylactic acid were mixed together and a BDNF-loaded composite conduit was fabricated by solvent evaporation method. The bioactivity of BDNF released from the composite conduit...