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Journal of Pharmaceutical Sciences
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23237
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#1Huanhuan Su (Chinese PLA General Hospital)
#2Fenghua Xu (Chinese PLA General Hospital)
Last. Yi Zhao (MCPHS University)
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Abstract The treatment of peripheral nerve injury is still a challenge. The present study was aimed to fabricate a composite nerve conduit containing slow-released brain-derived neurotrophic factor (BDNF) and evaluate its therapeutic effects on peripheral nerve defect. BDNF and polylactic acid (PLA) were mixed together and a BDNF-loaded composite conduit was fabricated by solvent evaporation method. The bioactivity of BDNF released from the composite conduit was measured by MTT assay. A rat scia...
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Proper prediction of human pharmacokinetic (PK) profiles can accelerate the compound selection in drug discovery. Recently, we reported a robust bottom-up physiologically-based pharmacokinetic (PBPK) approach (J Pharm Sci. 2019 Aug;108(8):2718-2727), which uses the in vivo rat distribution volume at the steady state (Vss) to determine human tissue-to-plasma partition coefficients (Kptissue). Here, we report on a bottom-up PBPK approach that can simulate the PK profile with both high-throughput a...
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#1Laura Risaliti (UniFI: University of Florence)H-Index: 2
#2Moira Ambrosi (UniFI: University of Florence)H-Index: 10
Last. Anna Rita Bilia (UniFI: University of Florence)H-Index: 36
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Abstract: Ascorbic acid has a unique role in the prevention and treatment of a large number of chronic diseases, including skin disorders but it can hardly penetrate the skin due to its solubility in water and its high instability. This study explored the formation of phosphatidylcholine-based vesicles upon addition of ascorbyl octanoate or decanoate, and their potential value as drug delivery systems. Khellin, a natural furanochromone with numerous applications in skin pathologies was loaded as...
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#1Coralie A. Richard (Eli Lilly and Company)
#2Tingting Wang (Eli Lilly and Company)
Last. Sarah L. Clark (Eli Lilly and Company)
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Abstract Numerous interactions can arise at the interface between the glass barrel / silicone oil coating / aqueous formulation in pre-filled syringes that can affect the functionality of the medical device. In this study, the Young-Dupre equation was applied at these interfaces to correlate the interfacial tension between the silicone oil coating and aqueous formulation to the functionality of the syringe. It was shown that lower silicone oil / drug product formulation interfacial tension led t...
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Abstract Orodispersible Film (ODF) is a promising and progressive dosage form that offers exceptional drug delivery benefits to patients. Indeed, they are the most transformational alternatives to traditional or conventional tablets or capsule dosage forms. ODFs are portable and highly comfortable for self-administration by patients with swallowing problems. The key to gain end-user acceptance is to have an ODF with outstanding quality, as poor quality may lead to choking or spitting of ODF, acc...
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#1Melissa M. Pressnall (KU: University of Kansas)H-Index: 2
#2Sebastian G. Huayamares (KU: University of Kansas)
Last. Cory Berkland (KU: University of Kansas)H-Index: 42
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Abstract Activation of the immune system to treat cancer has emerged as a powerful therapy tool, however, treatments must overcome the immunosuppressive microenvironment established by tumors. Toll-like receptor (TLR) agonists like CpG and polyI:C are potent stimulators of non-specific, pro-inflammatory immune responses, targeting TLR9 and TLR3, respectively. While these immunostimulants seem promising, systemic exposure can eventually induce severe side effects. Adverse inflammatory reactions i...
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#1Keishi Yamasaki (Sojo University)H-Index: 21
#2Keiki Sakurama (Sojo University)H-Index: 1
Last. Kazuaki Taguchi (Sojo University)H-Index: 13
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Abstract Daptomycin, a cyclic lipopeptide antibiotic, is clinically used for the treatment of infections caused by Gram-positive bacteria, including the methicillin-resistant Staphylococcus aureus and the vancomycin-resistant Enterococci. While daptomycin shows high plasma protein binding (90-93 %), our knowledge of the binding process is not extensive. To address this issue in more detail, we characterized the binding of daptomycin to plasma proteins and the findings indicate that the associati...
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#1Mukesh K. Mahajan (GSK: GlaxoSmithKline)H-Index: 5
#2Elizabeth J. Rivera (GSK: GlaxoSmithKline)H-Index: 2
Last. John Bertin (GSK: GlaxoSmithKline)H-Index: 54
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Abstract Receptor Interacting Protein 2 (RIP2) kinase inhibitors have been reported for therapeutic opportunities in inflammatory bowel diseases such as Ulcerative Colitis and Crohn’s disease. During lead optimization, team identified 4-aminoquinoline series and several compounds from this series were investigated in rat and dog pharmacokinetic studies. While compounds such as GSKA and GSKB demonstrated acceptable pharmacokinetics in rat and dog, further progression of these compounds was halted...
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#1Junsheng Xue (PKU: Peking University)H-Index: 2
#2Daming Kong (PKU: Peking University)
Last. Lin Shen (PKU: Peking University)
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Abstract SI-B001 is a new EGFR/HER3 bi-specific antibody showing encouraging anti-tumor efficacy in the preclinical studies and was ready for further clinical research. To help with the dose design, human pharmacokinetics (PK) and clinical effective doses of SI-B001 were predicted by PK and PK/PD modeling and simulation. A Michaels-Menten (M-M) PK model was first used to describe the PK of SI-B001 in cynomolgus monkeys, whose parameters were allometrically scaled to humans for the simulation of ...
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#1Lingling Ye (Fujian Medical University)
#2Meng Ke (Fujian Medical University)
Last. Cuihong Lin (Fujian Medical University)
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Abstract Ertapenem is a widely used antibiotic; however, its pharmacokinetics has not been fully evaluated in children with renal impairment. A physiologically based pharmacokinetic (PBPK) model of ertapenem was established and validated to simulate its disposition in the healthy population and adults with renal impairment, as well as to predict the exposure in pediatric patients with renal impairment. The simulated PBPK modeling results and the observed data of ertapenem after intravenous admin...
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