Complement-Independent Modulation of Influenza A Virus Infection by Factor H
Abstract
The complement system is an ancient innate immune defence mechanism that can recognise molecular patterns on the invading pathogens. Factor H, as an inhibitor of the alternative pathway, down-regulates complement activation on the host cell surface. Locally synthesised factor H at the site of infection/injury, including lungs, can act as a pattern recognition molecule without involving complement activation. Here, we report that factor H, a...
Paper Details
Title
Complement-Independent Modulation of Influenza A Virus Infection by Factor H
Published Date
Mar 25, 2020
Journal
Volume
11
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