Single-molecule displacement mapping unveils nanoscale heterogeneities in intracellular diffusivity
Abstract
Intracellular diffusion underlies vital cellular processes. However, it remains difficult to elucidate how an unbound protein diffuses inside the cell with good spatial resolution and sensitivity. Here we introduce single-molecule displacement/diffusivity mapping (SMdM), a super-resolution strategy that enables the nanoscale mapping of intracellular diffusivity through local statistics of the instantaneous displacements of freely diffusing...
Paper Details
Title
Single-molecule displacement mapping unveils nanoscale heterogeneities in intracellular diffusivity
Published Date
Mar 16, 2020
Journal
Volume
17
Issue
5
Pages
524 - 530
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