Molecular basis of P[II] major human rotavirus VP8* domain recognition of histo-blood group antigens
Abstract
Initial cell attachment of rotavirus (RV) to specific cell surface glycan receptors, which is the essential first step in RV infection, is mediated by the VP8* domain of the spike protein VP4. Recently, human histo-blood group antigens (HBGAs) have been identified as receptors or attachment factors for human RV strains. RV strains in the P[4] and P[8] genotypes of the P[II] genogroup share common recognition of the Lewis b (Leb) and H type 1...
Paper Details
Title
Molecular basis of P[II] major human rotavirus VP8* domain recognition of histo-blood group antigens
Published Date
Mar 24, 2020
Journal
Volume
16
Issue
3
Pages
e1008386 - e1008386
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