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PLOS Pathogens
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#1Julie Boucau (Ragon Institute of MGH, MIT and Harvard)H-Index: 5
#2Jishnu Das (University of Pittsburgh)
Last. Sylvie Le Gall (Ragon Institute of MGH, MIT and Harvard)H-Index: 30
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Latency reversal agents (LRA) variably induce HIV re-expression in CD4 T cells but reservoirs are not cleared. Whether HIV epitope presentation is similar between latency reversal and initial infection of CD4 T cells is unknown yet crucial to define immune responses able to detect HIV-infected CD4 T cells after latency reversal. HIV peptides displayed by MHC comes from the intracellular degradation of proteins by proteasomes and post-proteasomal peptidases but the impact of LRAs on antigen proce...
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#1Daniel Storey ('QUB': Queen's University Belfast)
#2Alan McNally (University of Birmingham)H-Index: 21
Last. María Molina (Complutense University of Madrid)H-Index: 28
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Klebsiella pneumoniae is recognized as an urgent threat to human health due to the increasing isolation of multidrug resistant strains. Hypervirulent strains are a major concern due to their ability to cause life-threating infections in healthy hosts. The type VI secretion system (T6SS) is widely implicated in microbial antagonism, and it mediates interactions with host eukaryotic cells in some cases. In silico search for genes orthologous to T6SS component genes and T6SS effector genes across 7...
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#1Nídia Sequeira Trovão (NIH: National Institutes of Health)H-Index: 7
#2Martha I. Nelson (NIH: National Institutes of Health)H-Index: 30
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#1Kai Rathje (CAU: University of Kiel)
Last. Alexander Klimovich (CAU: University of Kiel)H-Index: 6
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Interactions between microorganisms and their eukaryotic hosts have shaped the evolution of complex life forms - plants and animals. All extant multicellular organisms contain abundant and diverse microbiota, and are considered as metaorganisms or holobionts. It is widely accepted that an intricate balance between cell dynamics within the host, associated microbiota, and their proper adjustment to the environment maintain the integrity of such a metaorganism. However, it remains unclear, to what...
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#1Jing Wang (NAU: Nanjing Agricultural University)H-Index: 4
#2Huan‐Huan Ma (NAU: Nanjing Agricultural University)
Last. Yidong Wu (NAU: Nanjing Agricultural University)H-Index: 30
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Evolution of pest resistance reduces the efficacy of insecticidal proteins from the gram-positive bacterium Bacillus thuringiensis (Bt) used widely in sprays and transgenic crops. Better understanding of the genetic basis of resistance is needed to more effectively monitor, manage, and counter pest resistance to Bt toxins. Here we used CRISPR/Cas9 gene editing to clarify the genetics of Bt resistance and the associated effects on susceptibility to other microbial insecticides in one of the world...
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#1Wenbiao Wang (JNU: Jinan University)H-Index: 2
#2Dingwen Hu (WHU: Wuhan University)
Last. Feng Xiao (WHU: Wuhan University)H-Index: 2
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One of the fundamental reactions of the innate immune responses to pathogen infection is the release of pro-inflammatory cytokines, including IL-1β, processed by the NLRP3 inflammasome. The stimulator of interferon genes (STING) has the essential roles in innate immune response against pathogen infections. Here we reveal a distinct mechanism by which STING regulates the NLRP3 inflammasome activation, IL-1β secretion, and inflammatory responses in human cell lines, mice primary cells, and mice. I...
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#1Juanjuan Wang (Center for Infectious Disease Research and Policy)H-Index: 2
#2Jing-Wen Li (Center for Infectious Disease Research and Policy)H-Index: 2
Last. Jing-Ren Zhang (Center for Infectious Disease Research and Policy)H-Index: 5
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Streptococcus pneumoniae is well known for phase variation between opaque (O) and transparent (T) colonies within clonal populations. While the O variant is specialized in invasive infection (with a thicker capsule and higher resistance to host clearance), the T counterpart possesses a relatively thinner capsule and thereby higher airway adherence and colonization. Our previous study found that phase variation is caused by reversible switches of the “opaque ON-or-OFF” methylomes or methylation p...
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#1Xin Wu (Georgia Institute of Technology)H-Index: 1
#2Amelia R. I. Lindsey (UCR: University of California, Riverside)H-Index: 6
Last. Soojin V. Yi (Georgia Institute of Technology)H-Index: 37
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Wolbachia are maternally transmitted intracellular bacteria that induce a range of pathogenic and fitness-altering effects on insect and nematode hosts. In parasitoid wasps of the genus Trichogramma, Wolbachia infection induces asexual production of females, thus increasing transmission of Wolbachia. It has been hypothesized that Wolbachia infection accompanies a modification of the host epigenome. However, to date, data on genome-wide epigenomic changes associated with Wolbachia are limited, an...
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#1Kyousuke KobayashiH-Index: 2
#2Katsumi MizutaH-Index: 27
Last. Satoshi KoikeH-Index: 21
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Enterovirus 71 (EV71) is a causative agent of hand, foot, and mouth disease (HFMD). However, this infection is sometimes associated with severe neurological complications. Identification of neurovirulence determinants is important to understand the pathogenesis of EV71. One of the problems in evaluating EV71 virulence is that its genome sequence changes rapidly during replication in cultured cells. The factors that induce rapid mutations in the EV71 genome in cultured cells are unclear. Here, we...
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