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PLOS Pathogens
IF
6.46
Papers
10065
Papers 10166
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Published in PLOS Pathogens 6.46
Bart A. Eijkelkamp16
Estimated H-index: 16
(University of Adelaide),
Jacqueline R. Morey5
Estimated H-index: 5
(University of Adelaide)
+ -3 AuthorsDavid Clases3
Estimated H-index: 3
Human zinc deficiency increases susceptibility to bacterial infection. Although zinc supplementation therapies can reduce the impact of disease, the molecular basis for protection remains unclear. Streptococcus pneumoniae is a major cause of bacterial pneumonia, which is prevalent in regions of zinc deficiency. We report that dietary zinc levels dictate the outcome of S. pneumoniae infection in a murine model. Dietary zinc restriction impacts murine tissue zinc levels with distribution post-infe...
Published in PLOS Pathogens 6.46
Jochem B. Buil4
Estimated H-index: 4
(Radboud University Nijmegen),
Rasmus Krøger Hare2
Estimated H-index: 2
(SSI: Statens Serum Institut)
+ -3 AuthorsPaul E. Verweij66
Estimated H-index: 66
(Radboud University Nijmegen)
Published in PLOS Pathogens 6.46
Sivan Laviad-Shitrit2
Estimated H-index: 2
(University of Haifa),
Ido Izhaki31
Estimated H-index: 31
(University of Haifa),
Malka Halpern24
Estimated H-index: 24
(University of Haifa)
Vibrio cholerae is the causative agent of cholera, a life-threatening diarrheal disease. Cholera causes epidemics and pandemics, but the ways this disease spreads worldwide is still unclear. This review highlights a relatively new hypothesis regarding the way V. cholerae can be globally dispersed. Copepods and chironomids are natural reservoirs of V. cholerae and are part of different fish species’ diet. Furthermore, V. cholerae inhabits marine and freshwater fish species. Waterbird species feed...
Published in PLOS Pathogens 6.46
Tra-My Duong-Nu1
Estimated H-index: 1
(Chonnam National University),
Kwangjoon Jeong7
Estimated H-index: 7
(Chonnam National University)
+ -3 AuthorsJoon Haeng Rhee31
Estimated H-index: 31
(Chonnam National University)
The tad operons encode the machinery required for adhesive Flp (fimbrial low-molecular-weight protein) pili biogenesis. Vibrio vulnificus, an opportunistic pathogen, harbors three distinct tad loci. Among them, only tad1 locus was highly upregulated in in vivo growing bacteria compared to in vitro culture condition. To understand the pathogenic roles of the three tad loci during infection, we constructed single, double and triple tad loci deletion mutants. Interestingly, only the Δtad123 triple ...
Published in PLOS Pathogens 6.46
Pan Cao1
Estimated H-index: 1
(WHU: Wuhan University),
Wei-Wei Luo4
Estimated H-index: 4
(CAS: Chinese Academy of Sciences)
+ -3 AuthorsShu Li14
Estimated H-index: 14
(WHU: Wuhan University)
Recognition of viral RNA by the retinoic acid-inducible gene-I (RIG-I)-like receptors (RLRs), including RIG-I and MDA5, initiates innate antiviral responses. Although regulation of RLR-mediated signal transduction has been extensively investigated, how the recognition of viral RNA by RLRs is regulated remains enigmatic. In this study, we identified heterogeneous nuclear ribonucleoprotein M (hnRNPM) as a negative regulator of RLR-mediated signaling. Overexpression of hnRNPM markedly inhibited RNA...
Published in PLOS Pathogens 6.46
Xuehuo Zeng1
Estimated H-index: 1
(Case Western Reserve University),
Cathleen R. Carlin21
Estimated H-index: 21
(Case Western Reserve University)
The host limits adenovirus infections by mobilizing immune systems directed against infected cells that also represent major barriers to clinical use of adenoviral vectors. Adenovirus early transcription units encode a number of products capable of thwarting antiviral immune responses by co-opting host cell pathways. Although the EGF receptor (EGFR) was a known target for the early region 3 (E3) RIDα protein encoded by nonpathogenic group C adenoviruses, the functional role of this host-pathogen...
Published in PLOS Pathogens 6.46
Matthew R. Doremus1
Estimated H-index: 1
(UA: University of Arizona),
Suzanne E. Kelly15
Estimated H-index: 15
(UA: University of Arizona),
Martha S. Hunter29
Estimated H-index: 29
(UA: University of Arizona)
Terrestrial arthropods, including insects, commonly harbor maternally inherited intracellular symbionts that confer benefits to the host or manipulate host reproduction to favor infected female progeny. These symbionts may be especially vulnerable to thermal stress, potentially leading to destabilization of the symbiosis and imposing costs to the host. For example, increased temperatures can reduce the density of a common reproductive manipulator, Wolbachia, and the strength of its crossing inco...
Published in PLOS Pathogens 6.46
Natália Ketelut-Carneiro3
Estimated H-index: 3
(USP: University of São Paulo),
Camila Oliveira Silva Souza1
Estimated H-index: 1
(USP: University of São Paulo)
+ -3 AuthorsJoão S. Silva62
Estimated H-index: 62
(USP: University of São Paulo)
The granulomatous lesion resulting from infection with the fungus Paracoccidioides brasiliensis is characterized by a compact aggregate of mature cells, surrounded by a fibroblast- and collagen-rich content. Granuloma formation requires signaling elicited by inflammatory molecules such as members of the interleukin-1 family. Two members of this family have been thoroughly studied, namely IL-1α and IL-1β. In this study, we addressed the mechanisms underlying IL-1α secretion and its functional rol...
Published in PLOS Pathogens 6.46
Judith Grau-Expósito2
Estimated H-index: 2
(Autonomous University of Barcelona),
Laura Luque-Ballesteros (Autonomous University of Barcelona)+ -3 AuthorsMario Martin-Castillo (Autonomous University of Barcelona)
Latency reversal agents (LRAs) have proven to induce HIV-1 transcription in vivo but are ineffective at decreasing the size of the latent reservoir in antiretroviral treated patients. The capacity of the LRAs to perturb the viral reservoir present in distinct subpopulations of cells is currently unknown. Here, using a new RNA FISH/flow ex vivo viral reactivation assay, we performed a comprehensive assessment of the viral reactivation capacity of different families of LRAs, and their combinations...
Published in PLOS Pathogens 6.46
Brenda M. Calderon2
Estimated H-index: 2
(Emory University),
Shamika Danzy7
Estimated H-index: 7
(Emory University)
+ -3 AuthorsJohn Steel23
Estimated H-index: 23
(Emory University)
The M segment of the 2009 pandemic influenza A virus (IAV) has been implicated in its emergence into human populations. To elucidate the genetic contributions of the M segment to host adaptation, and the underlying mechanisms, we examined a panel of isogenic viruses that carry avian- or human-derived M segments. Avian, but not human, M segments restricted viral growth and transmission in mammalian model systems, and the restricted growth correlated with increased expression of M2 relative to M1....
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