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PLOS Pathogens
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A. MICs of monoculture- and co-culture- evolved E. coli isolates containing wild-type or mutant prc. B. Monoculture and coculture growth rates of monoculture-evolved E. coli isolates containing wild-type or mutant prc. C. Monoculture and coculture growth rates of co-culture-evolved E. coli isolates containing wild-type or mutant prc. All p-values based on Mann-Whitney U tests. Each data point represents the average MIC for three isolates obtained from a single population. For each species- cultu...
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#1Elizabeth M. Adamowicz (UMN: University of Minnesota)H-Index: 4
#2Michaela Muza (UMN: University of Minnesota)
Last. William R. Harcombe (UMN: University of Minnesota)H-Index: 17
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With antibiotic resistance rates on the rise, it is critical to understand how microbial species interactions influence the evolution of resistance. In obligate mutualisms, the survival of any one species (regardless of its intrinsic resistance) is contingent on the resistance of its cross-feeding partners. This sets the community antibiotic sensitivity at that of the ‘weakest link’ species. In this study, we tested the hypothesis that weakest link dynamics in an obligate cross-feeding relations...
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#1Weihao Hong (Huaqiao University)
#2Wenzhao Cheng (Huaqiao University)
Last. Ruian Xu (Huaqiao University)
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Establishing latent infection but retaining the capability to reactivate in certain circumstance is an ingenious tactic for retroviruses to persist in vivo while evading host immune surveillance. Many evidences indicate that Human T-cell leukemia virus type 1 (HTLV-1) is not completely silent in vivo. However, signals that trigger HTLV-1 latency-reactivation switching remain poorly understood. Here, we show that aryl hydrocarbon receptor (AHR), a ligand-activated transcription factor, plays a cr...
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#2Tianjun XuH-Index: 4
Last. Lei ZhangH-Index: 1
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#1Qing Chu (Shanghai Ocean University)
#2Tianjun XuH-Index: 4
Last. Lei Zhang (Shanghai Ocean University)H-Index: 1
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Increasing evidence suggests important roles for long noncoding RNAs (lncRNAs) as new gene modulators involved in various biological processes. However, the function roles of lncRNAs in lower vertebrates are still unknown. Here, we firstly identify a lncRNA, named MAVS antiviral-related lncRNA (MARL), as a key regulator for antiviral immunity in teleost fish. The results indicate that fish MAVS play essential roles in host antiviral responses and inhibition of Siniperca chuatsi rhabdovirus (SCRV...
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#1Mitsuhiro Nishimura (Kobe University)H-Index: 2
#2Bernadette Dian Novita (Kobe University)
Last. Taiki Aoshi (Osaka University)H-Index: 26
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A unique glycoprotein is expressed on the virus envelope of human herpesvirus 6B (HHV-6B): the complex gH/gL/gQ1/gQ2 (hereafter referred to as the HHV-6B tetramer). This tetramer recognizes a host receptor expressed on activated T cells: human CD134 (hCD134). This interaction is essential for HHV-6B entry into the susceptible cells and is a determinant for HHV-6B cell tropism. The structural mechanisms underlying this unique interaction were unknown. Herein we solved the interactions between the...
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#1Melissa Kane (University of Pittsburgh)H-Index: 1
#2Vincent Mele (University of Pittsburgh)
Last. Paul D. Bieniasz (Rockefeller University)H-Index: 67
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The foamy viruses (FV) or spumaviruses are an ancient subfamily of retroviruses that infect a variety of vertebrates. FVs are endemic, but apparently apathogenic, in modern non-human primates. Like other retroviruses, FV replication is inhibited by type-I interferon (IFN). In a previously described screen of IFN-stimulated genes (ISGs), we identified the macaque PHD finger domain protein-11 (PHF11) as an inhibitor of prototype foamy virus (PFV) replication. Here, we show that human and macaque P...
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#1Johannes NemethH-Index: 14
#2Gregory S. OlsonH-Index: 4
Last. Kevin B. UrdahlH-Index: 19
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CMTB and control mice were infected with ~2000–4000 CFU of mEmerald-expressing Mtb via aerosol and the cellularity of bronchoalveolar lavage (BAL) fluid extracted 24 hours following infection was analyzed by flow cytometry. Top panels: Flow cytometry plots showing mEmerald+ Mtb-infected AMs gated on CD45+CD11bintCD11c+CD64+SiglecF+ cells (see S17 Fig for gating strategy). Bottom panels: Distribution of infected cell types (left) and fraction of AMs infected (right) in BAL fluid at 24 hours follo...
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