Association between a TCF4 Polymorphism and Susceptibility to Schizophrenia

The basic helix-loop-helix (bHLH) transcription factor 4 ( TCF4 ) had been identified as a susceptibility gene associated with schizophrenia (SCZ) by GWAS, but inconsistent results have been found in other studies. To validate these findings and to reveal the effects of different inheritance models, rs2958182, rs1261085, rs8766, and rs12966547 of the TCF4 gene were genotyped in the Northwest Han Chinese population (448 cases and 628 controls)...