Molecular characterization of sorted malignant B cells from patients clinically identified with mantle cell lymphoma

•DNA–RNA sequencing correlation provides high-resolution lymphoma characterization.•Sorted MCL cells and B cells were used for optimal tumor exome and transcriptome analysis.•Intersected genome and transcriptome sequencing minimizes false-positive mutations.•Mutated genes in MCL patients are involved in the Notch signaling pathway or cross-talk.•Copy number and molecular profiles guide lymphoma subtype characterization. Mantle cell lymphoma...