Original paper
Antibodies that conformationally activate ADAMTS13 allosterically enhance metalloprotease domain function
Abstract
Plasma ADAMTS13 circulates in a folded conformation that is stabilized by an interaction between the central Spacer domain and the C-terminal CUB (complement components C1r and C1s, sea urchin protein Uegf, and bone morphogenetic protein-1) domains. Binding of ADAMTS13 to the VWF D4(-CK) domains or to certain activating murine monoclonal antibodies (mAbs) induces a structural change that extends ADAMTS13 into an open conformation that enhances...
Paper Details
Title
Antibodies that conformationally activate ADAMTS13 allosterically enhance metalloprotease domain function
Published Date
Mar 20, 2020
Journal
Volume
4
Issue
6
Pages
1072 - 1080
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Notes
History