Pharmacokinetics of double-dose cefuroxime in porcine intervertebral disc and vertebral cancellous bone—a randomized microdialysis study

BACKGROUND CONTEXT Postoperative pyogenic spondylodiscitis is associated with prolonged antimicrobial therapy and high relapse rates. Cefuroxime is a time-dependent antimicrobial widely used for intravenous perioperative prophylaxis in spine surgery. A previous study has indicated that a single dose of cefuroxime (1.5 g) provides insufficient spine tissue concentrations for spine procedures lasting more than 2 to 3 hours. PURPOSE To evaluate the...