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Mats Bue
Aarhus University Hospital
PharmacokineticsCancellous boneCefuroximeMicrodialysisMedicine
18Publications
5H-index
76Citations
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Publications 24
Newest
#1Pelle Hanberg (AU: Aarhus University)H-Index: 4
#1Pelle Hanberg (AU: Aarhus University)
Last. Maiken Stilling (AU: Aarhus University)H-Index: 12
view all 7 authors...
Abstract Background context Postoperative pyogenic spondylodiscitis is associated with prolonged antimicrobial therapy and high relapse rates. Cefuroxime is a time-dependent antimicrobial widely used for intravenous perioperative prophylaxis in spine surgery. A previous study has indicated that a single dose of cefuroxime (1.5 g) provides insufficient spine tissue concentrations for spine procedures lasting more than 2–3 hours. Purpose To evaluate the time with concentrations above relevant mini...
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#1Pelle Hanberg (Aarhus University Hospital)H-Index: 4
#1Pelle Hanberg (AU: Aarhus University)
Last. Maiken Stilling (AU: Aarhus University)H-Index: 12
view all 8 authors...
Abstract Microdialysis is a valuable pharmacokinetic tool for obtaining samples of drug concentrations from tissues of interest. When an absolute tissue concentration is needed, a calibration of the microdialysis catheter is required. The use of an internal standard offers a number of advantages compared to standard calibration methods. However, meticulous validation both in vitro and in vivo is needed, as this method requires an internal standard with physiochemical similarities to the analyte ...
1 CitationsSource
#1Mats BueH-Index: 5
#2Pelle HanbergH-Index: 4
Last. Hanne Birke-SørensenH-Index: 7
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BACKGROUND/AIM: It remains challenging to evaluate the in vivo pathophysiological biochemical characteristics in spine tissue, due to lack of an applicable model and feasible methods. The aim of this study was to apply microdialysis for the assessment of basic metabolites from the C3-C4 intervertebral disc, C3 vertebral cancellous bone and subcutaneous adipose tissue in a large porcine model. MATERIALS AND METHODS: In 7 pigs, glucose, pyruvate, lactate and glycerol concentrations were evaluated ...
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#1Hagen Schmal (OUH: Odense University Hospital)H-Index: 39
#2Michael Brix (OUH: Odense University Hospital)H-Index: 7
Last. Ilija Ban (Copenhagen University Hospital)
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Nonunions are a relevant economic burden affecting about 1.9% of all fractures. Rather than specifying a certain time frame, a nonunion is better defined as a fracture that will not heal without fu...
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#1Mats Bue (Aarhus University Hospital)H-Index: 5
#2Tomás Sou (Uppsala University)H-Index: 1
Last. Steffen Christensen (Aarhus University Hospital)H-Index: 23
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Abstract Objectives Piperacillin is a β-lactam antimicrobial frequently used in critically ill patients with acute kidney injury treated with continuous renal replacement therapy (CRRT). However, data regarding piperacillin tissue concentrations in this patient population is limited. We conducted a prospective observational study of free piperacillin concentrations during a single 8 h dosing interval in plasma (eight samples) and subcutaneous tissue (SCT) (thirteen samples) in 10 patients treate...
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#1Maja B ThomassenH-Index: 1
#2Pelle HanbergH-Index: 4
Last. Mats BueH-Index: 5
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Local treatment with gentamicin may be an important tool in the prevention and treatment of surgical site infections in high-risk procedures and patients. The aim of this study was to evaluate the pharmacokinetic profile of gentamicin in bone and surrounding tissue, released from a controlled application of a GentaColl sponge in a porcine model. In eight female pigs, a GentaColl sponge of 10 x 10 cm (1.3 mg gentamicin/cm(2) ) was placed in a cancellous bone cavity in the proximal tibia. Microdia...
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#1Mats Bue (AU: Aarhus University)H-Index: 5
#1Mats Bue (AU: Aarhus University)H-Index: 1
Last. Pelle Hanberg (AU: Aarhus University)
view all 7 authors...
Intra-articular injection of vancomycin may be an important antimicrobial prophylactic supplement to systemic administration in the prevention of prosthetic joint infections. In eight female pigs, 500 mg of diluted vancomycin was given by intra-articular injection into the knee joint. Microdialysis was used for dense sampling of vancomycin concentrations over 12 hours in the synovial fluid of the knee joint, and in the adjacent femoral and tibial cancellous bone and subcutaneous tissue. Venous b...
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#1Mikkel Tøttrup (AAU: Aalborg University)H-Index: 1
#2Kjeld Søballe (Aarhus University Hospital)H-Index: 53
Last. Mats Bue (Aarhus University Hospital)H-Index: 5
view all 8 authors...
1 CitationsSource
#1Pelle Hanberg (Aarhus University Hospital)H-Index: 4
#2Andrea Lund (Aarhus University Hospital)
Last. Mats Bue (Aarhus University Hospital)H-Index: 5
view all 4 authors...
Source
#1Mats BueH-Index: 5
#2Pelle HanbergH-Index: 4
Last. Kjeld SøballeH-Index: 53
view all 8 authors...
Aims Vancomycin may be an important drug for intravenous perioperative antimicrobial prophylaxis in spine surgery. We assessed single-dose vancomycin intervertebral disc, vertebral cancellous bone, and subcutaneous adipose tissue concentrations using microdialysis in a pig model. Methods 8 female pigs received 1,000 mg of vancomycin intravenously as a single dose over 100 minutes. Microdialysis probes were placed in the C3-C4 intervertebral disc, C3 vertebral cancellous bone, and subcutaneous ad...
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