Nrf2 deficiency in mice attenuates erythropoietic stress-related macrophage hypercellularity
Abstract
•CD169+ macrophages are depleted in Nrf2-deficient mice.•Deficiency of macrophages in Nrf2–/– mice significantly impaired macrophage and erythroid response to acute stress erythropoiesis.•Macrophage hypercellularity accompanies erythroid hyperplasia in sickle cell mice. Erythropoiesis in the bone marrow and spleen depends on intricate interactions between the resident macrophages and erythroblasts. Our study focuses on identifying the role of...
Paper Details
Title
Nrf2 deficiency in mice attenuates erythropoietic stress-related macrophage hypercellularity
Published Date
Apr 1, 2020
Journal
Volume
84
Pages
19 - 28.e4
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