Original paper
Regulated Proteolysis of MutSγ Controls Meiotic Crossing Over
Abstract
Crossover recombination is essential for accurate chromosome segregation during meiosis. The MutSγ complex, Msh4-Msh5, facilitates crossing over by binding and stabilizing nascent recombination intermediates. We show that these activities are governed by regulated proteolysis. MutSγ is initially inactive for crossing over due to an N-terminal degron on Msh4 that renders it unstable by directly targeting proteasomal degradation. Activation of...
Paper Details
Title
Regulated Proteolysis of MutSγ Controls Meiotic Crossing Over
Published Date
Apr 1, 2020
Journal
Volume
78
Issue
1
Pages
168 - 183.e5
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Notes
History